Sleep state instabilities in major depressive disorder: Detection and quantification with electrocardiogram-based cardiopulmonary coupling analysis.
Sleep state instabilities in major depressive disorder: Detection and quantification with electrocardiogram-based cardiopulmonary coupling analysis.
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DOI：
10.1111/j.1469-8986.2010.01060.x
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发表时间：
2011-02
期刊：
影响因子：
3.7
通讯作者：
Thomas RJ
中科院分区：
文献类型：
--
作者：
Yang AC;Yang CH;Hong CJ;Tsai SJ;Kuo CH;Peng CK;Mietus JE;Goldberger AL;Thomas RJ
睡眠中断是重度抑郁症的一个重要方面，但缺乏客观和廉价的评估手段。我们评估了基于心电图（ECG）的心肺耦合分析在量化重度抑郁症患者生理睡眠稳定性方面的效用。与对照组相比，未服药的抑郁症患者高频耦合（稳定睡眠指数）减少，低频耦合（不稳定睡眠指数）增加，极低频耦合（清醒/快速眼动睡眠指数）增加。服用药物的抑郁组显示稳定睡眠恢复到与对照组相当的水平。基于心电图的心肺耦合分析可能为量化睡眠质量/稳定性和客观评估重度抑郁症患者失眠的严重程度提供一种简单、经济的护理点方法。
Sleep disruption is an important aspect of major depressive disorder but lacks an objective and inexpensive means of assessment. We evaluated the utility of electrocardiogram (ECG)-based cardiopulmonary coupling analysis to quantify physiologic sleep stability in patients with major depression. Relative to controls, unmedicated depressed patients had a reduction in high-frequency coupling, an index of stable sleep, an increase in low-frequency coupling, an index of unstable sleep, and an increase in very-low-frequency coupling, an index of wakefulness/REM sleep. The medicated depressed group showed a restoration of stable sleep to a level comparable with that of the control group. ECG-based cardiopulmonary coupling analysis may provide a simple, cost-efficient point-of-care method to quantify sleep quality/stability and to objectively evaluate the severity of insomnia in patients with major depression.
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影响因子：
10.6
作者：
Jindal, RD;Thase, ME;Kupfer, DJ
通讯作者：
Kupfer, DJ
DOI：
10.1016/s0091-6773(75)91009-3
发表时间：
1975-01-01
期刊：
BEHAVIORAL BIOLOGY
影响因子：
--
作者：
SALETU, B
通讯作者：
SALETU, B
影响因子：
3.3
作者：
Irwin, MR;Valladares, EM;Ehlers, CL
通讯作者：
Ehlers, CL
影响因子：
3.1
作者：
Drevets, Wayne C.;Price, Joseph L.;Furey, Maura L.
通讯作者：
Furey, Maura L.
影响因子：
11.3
作者：
BUYSSE, DJ;REYNOLDS, CF;KUPFER, DJ
通讯作者：
KUPFER, DJ