The role of epigenetics in multi-generational transmission of asthma: An NIAID workshop report-based narrative review.
The role of epigenetics in multi-generational transmission of asthma: An NIAID workshop report-based narrative review.
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表观遗传学在哮喘多代传播中的作用：一项基于NIAID研讨会报告的叙述性综述。
DOI：
10.1111/cea.14223
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发表时间：
2022-11
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
作者：
越来越多的证据表明，环境暴露可能对健康产生影响，这种影响可以代代相传，而不需要直接暴露于原始因素，例如祖父母吸烟对孙辈的影响。因此，应在了解跨代影响的情况下调查个人的健康状况。表观遗传因素是调节基因组活性的分子因素或过程，可能影响跨代效应。表观遗传的跨代遗传已在植物和动物中得到证实，但目前正在研究这一过程在人类中的存在和程度。动物实验数据支持哮喘风险从单次暴露于有害因素的几代人之间的传递，并表明这种传递的性质部分是由于DNA甲基化的变化，这是研究最多的表观遗传过程。父亲青春期前暴露与后代哮喘和肺功能缺陷风险的关联也可能是由表观遗传过程介导的。多代出生队列是研究疾病易感性跨代转移的存在和影响及其潜在机制的理想方法。然而，多代研究需要招募和评估几十年的参与者。对成年多代队列的调查资源密集程度较低，但存在回忆偏倚的风险。统计分析是具有挑战性的不同程度的纵向和层次的数据，但路径分析，结构方程建模和多层次建模可以采用，定向网络解决纵向效应值得探索，努力研究因果关系的途径。父母和祖父母的暴露影响其后代的哮喘风险，部分是通过跨代的表观遗传信息传递介导的。更好地了解这些影响将有助于更好地估计环境暴露造成的真实发病率和死亡率，并随后制定预防概念。最近的证据表明，祖父母的健康状况，营养和环境暴露可能会影响孙辈的健康结果。因此，对个体健康的风险不仅要考虑父母的遗传和暴露，而且要考虑祖父母和祖先的因素。虽然研究人员已经开始系统地研究DNA甲基化，但我们在其他表观遗传因素的研究中几乎没有触及表面。暴露的时间、测量表观基因组学的生物相关组织和遗传背景是重要的考虑因素。跨代研究可以为跨代效应提供有用的见解，特别是在孕前暴露信息可用的情况下。
There is mounting evidence that environmental exposures can result in effects on health that can be transmitted across generations, without the need for a direct exposure to the original factor, for example, the effect of grandparental smoking on grandchildren. Hence, an individual’s health should be investigated with the knowledge of cross-generational influences. Epigenetic factors are molecular factors or processes that regulate genome activity and may impact cross-generational effects. Epigenetic transgenerational inheritance has been demonstrated in plants and animals but the presence and extent of this process in humans is currently being investigated. Experimental data in animals support transmission of asthma risk across generations from a single exposure to the deleterious factor and suggest that the nature of this transmission is in part due to changes in DNA methylation, the most studied epigenetic process. The association of father’s prepuberty exposure with offspring risk of asthma and lung function deficit may also be mediated by epigenetic processes. Multigenerational birth cohorts are ideal to investigate the presence and impact of transfer of disease susceptibility across generations and underlying mechanisms. However, multigenerational studies require recruitment and assessment of participants over several decades. Investigation of adult multi-generation cohorts is less resource intensive but run the risk of recall bias. Statistical analysis is challenging given varying degrees of longitudinal and hierarchical data but path analyses, structural equation modelling and multilevel modelling can be employed, and directed networks addressing longitudinal effects deserve exploration as an effort to study causal pathways. Parental and grandparental exposures influence risk of asthma in their offspring, in part mediated by epigenetic transfer of information across generations. An improved understanding of these effects will help to better estimate the true morbidity and mortality resulting from environmental exposures, and subsequently to develop concepts for prevention. Recent evidence indicates that grand parental health status, nutrition, and environmental exposures might influence health outcomes in grandchildren. Therefore, the risk to individual’s health should consider not only parental genetics and exposures, but also grandparental and ancestral factors. While researchers have begun to systematically investigate DNA methylation, we have barely scratched the surface in the investigations of other epigenetic factors. Timing of exposures, biologically relevant tissues in which to measure epigenomics, and genetic background are important considerations. Cross generational studies can provide useful insights on transgenerational effect, especially where preconception exposure information is available.
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影响因子：
3.8
作者：
Ben Maamar M;Sadler-Riggleman I;Beck D;McBirney M;Nilsson E;Klukovich R;Xie Y;Tang C;Yan W;Skinner MK
通讯作者：
Skinner MK
DOI：
10.1016/j.jaci.2016.12.002
发表时间：
2017-02
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Arshad SH;Karmaus W;Zhang H;Holloway JW
通讯作者：
Holloway JW
影响因子：
4.4
作者：
Braback, Lennart;Lodge, Caroline J.;Forsberg, Bertil
通讯作者：
Forsberg, Bertil
影响因子：
5.7
作者：
Gao L;Liu X;Millstein J;Siegmund KD;Dubeau L;Maguire RL;Jim Zhang J;Fuemmeler BF;Kollins SH;Hoyo C;Murphy SK;Breton CV
通讯作者：
Breton CV
影响因子：
10.5
作者：
Berger, Shelley L.;Kouzarides, Tony;Shilatifard, Ali
通讯作者：
Shilatifard, Ali