Deciphering adipose tissue heterogeneity.
Deciphering adipose tissue heterogeneity.
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DOI：
10.1111/nyas.13398
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发表时间：
2018-01
影响因子：
5.2
通讯作者：
Tseng YH
中科院分区：
文献类型：
--
作者：
Lynes MD;Tseng YH
肥胖症是脂肪组织质量的过度积累，并且连同其后遗症，特别是II型糖尿病和代谢综合征，肥胖症呈现出重大的健康危机。虽然肥胖只是由脂肪量增加引起的，但人体脂肪组织的异质性意味着对能量平衡增加的反应是高度复杂的。具有相似表型的个体受试者对相同治疗的反应可能非常不同;因此，肥胖可能受益于个性化的精准医学方法。事实上，肥胖发展的差异是由性别、遗传和环境的差异驱动的，但也是由不同类型的脂肪组织以及组成脂肪组织的不同细胞类型驱动的。通过描述不同脂肪库中的不同细胞群，我们可以解释这些不同参与者在维持全身能量稳态中的复杂作用。为了进一步了解脂肪组织，成脂分化和脂质积累的转录程序必须调查。由于细胞和储存库的特定功能被描述，它们可以被放置在能量过剩的背景下，以了解脂肪组织的异质性如何塑造个人的代谢状态和条件。
Obesity is an excess accumulation of adipose tissue mass, and, together with its sequelae, in particular type II diabetes and metabolic syndrome, obesity presents a major health crisis. Although obesity is simply caused by increased adipose mass, the heterogeneity of adipose tissue in humans means that the response to increased energy balance is highly complex. Individual subjects with similar phenotypes may respond very differently to the same treatments; therefore, obesity may benefit from a personalized precision medicine approach. The variability in the development of obesity is indeed driven by differences in sex, genetics, and environment, but also by the various types of adipose tissue as well as the different cell types that compose it. By describing the distinct cell populations that reside in different fat depots, we can interpret the complex effect of these various players in the maintenance of whole-body energy homeostasis. To further understand adipose tissue, adipogenic differentiation and the transcriptional program of lipid accumulation must be investigated. As the cell- and depot-specific functions are described, they can be placed in the context of energy excess to understand how the heterogeneity of adipose tissue shapes individual metabolic status and condition.
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DOI：
10.1152/physiol.00010.2011
发表时间：
2011-08
期刊：
Physiology (Bethesda, Md.)
影响因子：
--
作者：
Cantó C;Auwerx J
通讯作者：
Auwerx J
影响因子：
16.6
作者：
Berbée JF;Boon MR;Khedoe PP;Bartelt A;Schlein C;Worthmann A;Kooijman S;Hoeke G;Mol IM;John C;Jung C;Vazirpanah N;Brouwers LP;Gordts PL;Esko JD;Hiemstra PS;Havekes LM;Scheja L;Heeren J;Rensen PC
通讯作者：
Rensen PC
影响因子：
3.3
作者：
Cohen P;Spiegelman BM
通讯作者：
Spiegelman BM
影响因子：
4.1
作者：
Cassard-Doulcier, AM;Gelly, C;Ricquier, D
通讯作者：
Ricquier, D
DOI：
10.1038/ijosup.2015.9
发表时间：
2015-08-01
期刊：
International journal of obesity supplements
影响因子：
--
作者：
Bartness, T J;Ryu, V
通讯作者：
Ryu, V