Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol.
Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol.
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DOI：
10.1007/s00125-011-2204-7
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发表时间：
2011-10
期刊：
影响因子：
8.2
通讯作者：
Taylor, R.
中科院分区：
文献类型：
--
作者：
Lim, E. L.;Hollingsworth, K. G.;Aribisala, B. S.;Chen, M. J.;Mathers, J. C.;Taylor, R.
2型糖尿病被认为是不可避免的进展，具有不可逆的β细胞衰竭。该假设被检验，即β细胞衰竭和胰岛素抵抗都可以通过饮食限制能量摄入来逆转。11名2型糖尿病患者（49.5 ± 2.5岁，BMI 33.6 ± 1.2 kg/m2，9名男性和2名女性）在2.5 MJ（600 kcal）/天饮食前和后1，4和8周进行了研究。测量基础肝葡萄糖输出量、肝脏和外周胰岛素敏感性和β细胞功能。使用三点狄克逊磁共振成像测量胰腺和肝脏三酰甘油含量。一个年龄，性别和体重相匹配的8名非糖尿病参与者进行了研究。限制能量摄入1周后，糖尿病组的空腹血糖恢复正常（从9.2 ± 0.4至5.9 ± 0.4 mmol/l; p = 0.003）。胰岛素对肝葡萄糖输出的抑制从43 ± 4%改善至74 ± 5%（p = 0.003 vs基线;对照组68 ± 5%）。肝脏三酰甘油含量从糖尿病组的12.8 ± 2.4%降至第8周的2.9 ± 0.2%（p = 0.003）。第一时相胰岛素反应在研究期间增加（0.19 ± 0.02至0.46 ± 0.07 nmol min−1 m−2; p < 0.001），并接近对照值（0.62 ± 0.15 nmol min−1 m−2; p = 0.42）。最大胰岛素反应在第8周时变得超常（1.37 ± 0.27 vs对照组1.15 ± 0.18 nmol min−1 m−2）。胰三酰甘油从8.0 ± 1.6%降至6.2 ± 1.1%（p = 0.03）。2型糖尿病患者的β细胞功能和肝脏胰岛素敏感性的正常化仅通过饮食能量限制实现。这与胰腺和肝脏三酰甘油储存减少有关。2型糖尿病的基础异常是可逆的，通过减少饮食能量摄入。
Type 2 diabetes is regarded as inevitably progressive, with irreversible beta cell failure. The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake. Eleven people with type 2 diabetes (49.5 ± 2.5 years, BMI 33.6 ± 1.2 kg/m2, nine male and two female) were studied before and after 1, 4 and 8 weeks of a 2.5 MJ (600 kcal)/day diet. Basal hepatic glucose output, hepatic and peripheral insulin sensitivity and beta cell function were measured. Pancreas and liver triacylglycerol content was measured using three-point Dixon magnetic resonance imaging. An age-, sex- and weight-matched group of eight non-diabetic participants was studied. After 1 week of restricted energy intake, fasting plasma glucose normalised in the diabetic group (from 9.2 ± 0.4 to 5.9 ± 0.4 mmol/l; p = 0.003). Insulin suppression of hepatic glucose output improved from 43 ± 4% to 74 ± 5% (p = 0.003 vs baseline; controls 68 ± 5%). Hepatic triacylglycerol content fell from 12.8 ± 2.4% in the diabetic group to 2.9 ± 0.2% by week 8 (p = 0.003). The first-phase insulin response increased during the study period (0.19 ± 0.02 to 0.46 ± 0.07 nmol min−1 m−2; p < 0.001) and approached control values (0.62 ± 0.15 nmol min−1 m−2; p = 0.42). Maximal insulin response became supranormal at 8 weeks (1.37 ± 0.27 vs controls 1.15 ± 0.18 nmol min−1 m−2). Pancreatic triacylglycerol decreased from 8.0 ± 1.6% to 6.2 ± 1.1% (p = 0.03). Normalisation of both beta cell function and hepatic insulin sensitivity in type 2 diabetes was achieved by dietary energy restriction alone. This was associated with decreased pancreatic and liver triacylglycerol stores. The abnormalities underlying type 2 diabetes are reversible by reducing dietary energy intake.
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影响因子：
5.8
作者：
Laferrere, Blandine;Teixeira, Julio;Olivan, Blanca
通讯作者：
Olivan, Blanca
影响因子：
7.7
作者：
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通讯作者：
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DOI：
10.1074/jbc.m109.064501
发表时间：
2010-02-26
期刊：
The Journal of biological chemistry
影响因子：
--
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通讯作者：
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29.4
作者：
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影响因子：
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作者：
D'Adamo E;Cali AM;Weiss R;Santoro N;Pierpont B;Northrup V;Caprio S
通讯作者：
Caprio S