The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population.
The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population.
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DOI：
10.1186/1744-9081-6-50
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发表时间：
2010-08-30
期刊：
影响因子：
--
通讯作者：
Sora I
中科院分区：
文献类型：
--
作者：
Kobayashi H;Ujike H;Iwata N;Inada T;Yamada M;Sekine Y;Uchimura N;Iyo M;Ozaki N;Itokawa M;Sora I
多项证据表明，多巴胺能神经系统导致甲基苯丙胺 (METH) 依赖，并且越来越多的证据表明多巴胺和腺苷受体之间存在拮抗相互作用。因此，我们假设 A2A 腺苷受体 (ADORA2A) 基因的变异会改变对冰毒依赖/精神病的遗传易感性。我们首先分析了 METH 依赖/精神病患者 ADORA2A 基因的外显子和外显子-内含子边界的变化。然后，对总共 171 名冰毒依赖/精神病患者和 229 名对照者进行了这些单核苷酸多态性与冰毒依赖/精神病之间的关联分析。我们发现了 6 个变异，其中一个单核苷酸多态性 (SNP) 是新颖的。 Exon2+751 (rs5751876) SNP 的等位基因频率和基因型频率与 METH 依赖/精神病之间存在显着关联。这些关联在女性中尤其明显。在临床特征分析中，观察到 SNP 与单独使用冰毒（即不同时使用其他滥用物质）的患者亚组之间存在显着关联。这些结果表明，ADORA2A 基因可能是 METH 依赖/精神病的脆弱因素，特别是在女性和/或仅使用 METH 的患者中。
Several lines of evidence suggest that the dopaminergic nervous system contributes to methamphetamine (METH) dependence, and there is increasing evidence of antagonistic interactions between dopamine and adenosine receptors. We therefore hypothesized that variations in the A2A adenosine receptor (ADORA2A) gene modify genetic susceptibility to METH dependence/psychosis. We first analyzed variations in the exons and exon-intron boundaries of the ADORA2A gene in METH dependent/psychotic patients. Then an association analysis between these single nucleotide polymorphisms and METH dependence/psychosis was performed using a total of 171 METH dependent/psychotic patients and 229 controls. We found 6 variations, of which one single nucleotide polymorphism (SNP) was novel. Significant associations were observed between the allelic and genotypic frequencies of the Exon2+751 (rs5751876) SNP and METH dependence/psychosis. These associations were observed especially in females. In the clinical feature analyses, significant associations were observed between the SNP and the patient subgroup using METH alone (i.e., without concomitant use of other substances of abuse). These results suggest that the ADORA2A gene could be a vulnerability factor for METH dependence/psychosis, especially in females and/or in patients using only METH.
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DOI：
10.1002/ajmg.b.30228
发表时间：
2005-11-05
影响因子：
2.8
作者：
Hohoff, C;McDonald, JM;de Wit, H
通讯作者：
de Wit, H
影响因子：
2.8
作者：
Ujike, H;Harano, M;Ozaki, N
通讯作者：
Ozaki, N
影响因子：
3.4
作者：
Munzar, P;Justinova, Z;Goldberg, SR
通讯作者：
Goldberg, SR
影响因子：
6.7
作者：
Ujike, Hiroshi
通讯作者：
Ujike, Hiroshi
影响因子：
7.6
作者：
Chen, JF;Moratalla, R;Schwarzschild, MA
通讯作者：
Schwarzschild, MA