Vinpocetine Suppresses Streptococcus pneumoniae-Induced Inflammation via Inhibition of ERK1 by CYLD.
Vinpocetine Suppresses Streptococcus pneumoniae-Induced Inflammation via Inhibition of ERK1 by CYLD.
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DOI：
10.4049/jimmunol.1901299
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发表时间：
2020-02-15
期刊：
影响因子：
--
通讯作者：
Li JD
中科院分区：
文献类型：
--
作者：
Komatsu K;Nam DH;Lee JY;Yoneda G;Yan C;Li JD
Otitis media (OM) is the most common bacterial infection in children. It remains a major health problem and a substantial socioeconomic burden. Streptococcus pneumoniae (S. pneumoniae) is one of the most common bacterial pathogens causing OM. Innate inflammatory response plays a critical role in host defense against bacterial pathogens. However, if excessive, it has a detrimental impact on the middle ear, leading to the middle ear inflammation, a hallmark of OM. Currently, there has been limited success in developing effective therapeutic agents to suppress inflammation without serious side effects. Here, we show that vinpocetine, an anti-stroke drug, suppressed S. pneumoniae-induced inflammatory response in cultured middle ear epithelial cells as well as in the middle ear of mice. Interestingly, vinpocetine inhibited S. pneumoniae-induced inflammation via upregulating a key negative regulator cylindromatosis (CYLD). Moreover, CYLD suppressed S. pneumoniae-induced inflammation via inhibiting the activation of extracellular signal-regulated kinase (ERK). Importantly, the post-infection administration of vinpocetine markedly inhibited middle ear inflammation induced by S. pneumoniae in a well-established mouse OM model. These studies provide insights into the molecular mechanisms underlying the tight regulation of inflammation via inhibition of ERK by CYLD and identified vinpocetine as a potential therapeutic agent for suppressing the inflammatory response in the pathogenesis of OM via upregulating negative regulator CYLD expression.
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影响因子：
3.7
作者：
Korona-Glowniak I;Zychowski P;Siwiec R;Mazur E;Niedzielska G;Malm A
通讯作者：
Malm A
影响因子：
158.5
作者：
Galiè, N;Ghofrani, HA;Simonneau, G
通讯作者：
Simonneau, G
DOI：
10.1177/0194599812459636
发表时间：
2013-04
期刊：
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
影响因子：
--
作者：
Murphy TF;Chonmaitree T;Barenkamp S;Kyd J;Nokso-Koivisto J;Patel JA;Heikkinen T;Yamanaka N;Ogra P;Swords WE;Sih T;Pettigrew MM
通讯作者：
Pettigrew MM
影响因子：
5.5
作者：
Kurabi A;Pak K;Ryan AF;Wasserman SI
通讯作者：
Wasserman SI
影响因子：
0.6
作者：
Bergenfelz, Caroline;Hakansson, Anders P
通讯作者：
Hakansson, Anders P