Glucagon-like peptide-1 (GLP-1) and protective effects in cardiovascular disease: a new therapeutic approach for myocardial protection.
Glucagon-like peptide-1 (GLP-1) and protective effects in cardiovascular disease: a new therapeutic approach for myocardial protection.
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DOI：
10.1186/1475-2840-12-90
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发表时间：
2013-06-18
影响因子：
9.3
通讯作者：
Zhao TC
中科院分区：
文献类型：
--
作者：
Zhao TC
胰高血糖素样肽-1(GLP-1)是胰升糖素原家族的一员，参与控制食欲和饱腹感。GLP-1具有胰岛素样作用、胰岛素样作用和降糖作用，从而在2型糖尿病患者中发挥多种互补作用来降低血糖。与传统胰岛素相比，GLP-1的一个主要优势是，GLP-1的促胰岛素作用依赖于环境中的葡萄糖浓度，从而减轻了低血糖的风险。最近，GLP-1在心血管疾病中的关键作用已在临床前和临床研究中被提出。实验数据表明，GLP-1及其类似物除了具有经典的血糖调节作用外，还对心血管系统有直接影响。在临床上，GLP-1对心肌缺血和心力衰竭的患者也有有益的效果。GLP-1最近被证明是治疗心肌损伤的一种更有效的替代方法。本文综述了GLP-1在缺血和非缺血心脏的实验动物模型和人体试验中应用的最新证据，并讨论了其分子机制和作为一种新的治疗方法的潜力。
Glucagon-like peptide-1 (GLP-1) is a member of the proglucagon incretin family implicated in the control of appetite and satiety. GLP-1 has insulinotropic, insulinomimetic, and glucagonostatic effects, thereby exerting multiple complementary actions to lower blood glucose in subjects with type 2 diabetes mellitus. A major advantage over conventional insulin is the fact that the insulinotropic actions of GLP-1 are dependent upon ambient glucose concentration, mitigating the risks of hypoglycemia. Recently, the crucial role of GLP-1 in cardiovascular disease has been suggested in both preclinical and clinical studies. The experimental data indicate GLP-1 and its analogs to have direct effects on the cardiovascular system, in addition to their classic glucoregulatory actions. Clinically, beneficial effects of GLP-1 have also been demonstrated in patients with myocardial ischemia and heart failure. GLP-1 has recently been demonstrated to be a more effective alternative in treating myocardial injury. This paper provides a review on the current evidence supporting the use of GLP-1 in experimental animal models and human trials with the ischemic and non-ischemic heart and discusses their molecular mechanisms and potential as a new therapeutic approach.
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