Hormone-replacement therapy influences gene expression profiles and is associated with breast-cancer prognosis: a cohort study.
Hormone-replacement therapy influences gene expression profiles and is associated with breast-cancer prognosis: a cohort study.
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激素替代疗法会影响基因表达谱，并与乳腺癌预后有关：一项队列研究。
DOI：
10.1186/1741-7015-4-16
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发表时间：
2006-06-30
期刊：
影响因子：
9.3
通讯作者：
Bergh, Jonas
中科院分区：
文献类型：
--
作者：
Hall, Per;Ploner, Alexander;Bjohle, Judith;Huang, Fei;Lin, Chin-Yo;Liu, Edison T.;Miller, Lance D.;Nordgren, Hans;Pawitan, Yudi;Shaw, Peter;Skoog, Lambert;Smeds, Johanna;Wedren, Sara;Ohd, John;Bergh, Jonas
绝经后激素替代疗法(HRT)会增加患乳腺癌的风险。然而，HRT对原发肿瘤生物学的影响还不是很清楚。我们使用Affymetrix人类基因组U133A阵列获得了乳腺癌基因表达谱。我们在72名绝经后妇女中研究了HRT调节的基因图谱、肿瘤特征和无复发生存率之间的关系。在雌激素受体(ER)蛋白阳性肿瘤患者(n=72)中，HRT的使用与276个基因的调节改变有关。基于这些基因的表达谱将ER阳性肿瘤分成两个分子亚类，其中一个与HRT的使用有关，尽管ER水平较低，但无复发生存率显著提高。与外部数据的比较表明，HRT相关肿瘤的基因调控与短期雌激素暴露诱导的基因调控呈负相关，但与他莫昔芬的疗效呈正相关。我们的发现表明，绝经后HRT的使用与不同的基因表达谱有关，这些基因表达谱与更好的无复发生存率和较低的ER蛋白水平有关。初步地，HRT相关基因在肿瘤中的表达类似于他莫昔芬对MCF-7细胞的影响。
Postmenopausal hormone-replacement therapy (HRT) increases breast-cancer risk. The influence of HRT on the biology of the primary tumor, however, is not well understood. We obtained breast-cancer gene expression profiles using Affymetrix human genome U133A arrays. We examined the relationship between HRT-regulated gene profiles, tumor characteristics, and recurrence-free survival in 72 postmenopausal women. HRT use in patients with estrogen receptor (ER) protein positive tumors (n = 72) was associated with an altered regulation of 276 genes. Expression profiles based on these genes clustered ER-positive tumors into two molecular subclasses, one of which was associated with HRT use and had significantly better recurrence free survival despite lower ER levels. A comparison with external data suggested that gene regulation in tumors associated with HRT was negatively correlated with gene regulation induced by short-term estrogen exposure, but positively correlated with the effect of tamoxifen. Our findings suggest that post-menopausal HRT use is associated with a distinct gene expression profile related to better recurrence-free survival and lower ER protein levels. Tentatively, HRT-associated gene expression in tumors resembles the effect of tamoxifen exposure on MCF-7 cells.
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影响因子：
3.8
作者：
Feigelson, HS;Jonas, CR;Calle, EE
通讯作者：
Calle, EE
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