Phage-Mediated Immune Evasion and Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Humans.
Phage-Mediated Immune Evasion and Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Humans.
复制标题
噬菌体介导的免疫逃避和牲畜相关甲氧西林抗甲氧西葡萄球菌金黄色葡萄球菌在人类中的传播。
DOI：
10.3201/eid2611.201442
复制
发表时间：
2020-11
影响因子：
11.8
通讯作者：
Larsen J
中科院分区：
文献类型：
--
作者：
Sieber RN;Urth TR;Petersen A;Møller CH;Price LB;Skov RL;Larsen AR;Stegger M;Larsen J
这些细菌能够适应人类，导致更多的传播到社区和医疗环境。家畜相关耐甲氧西林金黄色葡萄球菌（LA-MRSA）可以获得噬菌体编码的免疫调节剂，如免疫逃避簇（IEC），其保护细菌免受人类先天免疫系统的组分的侵害，以及TarP酶，其保护免受抗体介导的免疫识别。我们使用全基因组测序和流行病学调查来研究2004-2011年期间携带IEC和tarP的噬菌体对丹麦北部地区LA-MRSA家庭传播的影响。我们回顾了2007-2018年期间丹麦所有经历LA-MRSA感染的患者的信息，以确定IEC是否与一般人群的传播增加相关。在人类宿主中IEC的水平获取与LA-MRSA的家庭传播增加以及向社区和医疗环境的溢出有关，而我们没有发现任何证据表明IEC阳性LA-MRSA分离株在一般人群中已经自我维持。相比之下，TarP似乎没有影响LA-MRSA的家庭传播。
These bacteria are capable of adapting to humans, leading to increased spread into the community and healthcare settings. Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) can acquire phage-encoded immune modulators, such as the immune evasion cluster (IEC), which protects bacteria from components of the human innate immune system, and the enzyme TarP, which protects against antibody-mediated immune recognition. We used whole-genome sequencing and epidemiologic investigations to study the effects of IEC- and tarP-harboring phages on household transmission of LA-MRSA in North Denmark Region during 2004–2011. We reviewed information about all patients throughout Denmark who experienced LA-MRSA infection during 2007–2018 to determine whether IEC is associated with increased spread into the general population. Horizontal acquisition of IEC in the human host was associated with increased household transmission of LA-MRSA and spillover into the community and healthcare settings, whereas we found no evidence to suggest that IEC-positive LA-MRSA isolates have become self-sustainable in the general population. By contrast, TarP did not seem to influence household transmission of LA-MRSA.
登录
查看更多内容
影响因子：
6.4
作者：
Price LB;Stegger M;Hasman H;Aziz M;Larsen J;Andersen PS;Pearson T;Waters AE;Foster JT;Schupp J;Gillece J;Driebe E;Liu CM;Springer B;Zdovc I;Battisti A;Franco A;Zmudzki J;Schwarz S;Butaye P;Jouy E;Pomba C;Porrero MC;Ruimy R;Smith TC;Robinson DA;Weese JS;Arriola CS;Yu F;Laurent F;Keim P;Skov R;Aarestrup FM
通讯作者：
Aarestrup FM
影响因子：
11.8
作者：
van Cleef BA;Monnet DL;Voss A;Krziwanek K;Allerberger F;Struelens M;Zemlickova H;Skov RL;Vuopio-Varkila J;Cuny C;Friedrich AW;Spiliopoulou I;Pászti J;Hardardottir H;Rossney A;Pan A;Pantosti A;Borg M;Grundmann H;Mueller-Premru M;Olsson-Liljequist B;Widmer A;Harbarth S;Schweiger A;Unal S;Kluytmans JA
通讯作者：
Kluytmans JA
影响因子：
6.4
作者：
Falugi F;Kim HK;Missiakas DM;Schneewind O
通讯作者：
Schneewind O
在1999年至2011年，丹麦无牲畜接触的患者中，抗甲基肽的金黄色葡萄球菌CC398是疾病的越来越多的原因。
DOI：
10.2807/1560-7917.es.2015.20.37.30021
发表时间：
2015
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Larsen J;Petersen A;Sørum M;Stegger M;van Alphen L;Valentiner-Branth P;Knudsen LK;Larsen LS;Feingold B;Price LB;Andersen PS;Larsen AR;Skov RL
通讯作者：
Skov RL
DOI：
10.1093/cid/cix504
发表时间：
2017-10-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Larsen J;Petersen A;Larsen AR;Sieber RN;Stegger M;Koch A;Aarestrup FM;Price LB;Skov RL;Danish MRSA Study Group
通讯作者：
Danish MRSA Study Group