Transforming Growth Factor-β Signaling Regulates Tooth Root Dentinogenesis by Cooperation With Wnt Signaling.
Transforming Growth Factor-β Signaling Regulates Tooth Root Dentinogenesis by Cooperation With Wnt Signaling.
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转化生长因子-β 信号通过与 Wnt 信号合作调节牙根牙本质发生
DOI：
10.3389/fcell.2021.687099
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发表时间：
2021
影响因子：
5.5
通讯作者：
Yang G
中科院分区：
文献类型：
--
作者：
Zhang R;Lin J;Liu Y;Yang S;He Q;Zhu L;Yang X;Yang G
牙本质细胞的适当分化对于先前的研究至关重要。根骨丁素的ormal形成与骨质细胞的骨质分化相关。在OCN-CRE中表达Wnt拮抗剂DKK1； Rosa26DKK1小鼠开发了eTopic成骨分化，并阻止了牙源性分化。
Proper differentiation of odontoblasts is crucial for the development of tooth roots. Previous studies have reported the osteogenic/odontogenic potential of pre-odontoblasts during root odontoblast differentiation. However, the underlying molecular pathway that orchestrates these processes remains largely unclear. In this study, ablation of transforming growth factor-β receptor type 2 (Tgfbr2) in root pre-odontoblasts resulted in abnormal formation of root osteodentin, which was associated with ectopic osteogenic differentiation of root odontoblasts. Disrupting TGF-β signaling caused upregulation of Wnt signaling characterized by increased Wnt6, Wnt10a, Tcf-1, and Axin2 expression. Interestingly, inhibiting Wnt signaling by deleting Wntless (wls) in Osteocalcin (Ocn)-Cre; Tgfbr2fl/fl; Wlsfl/fl mice or overexpressing the Wnt antagonist Dkk1 in Ocn-Cre; Tgfbr2fl/fl; ROSA26Dkk1 mice decreased ectopic osteogenic differentiation and arrested odontoblast differentiation. Our results suggest that TGF-β signaling acts with Wnt signaling to regulate root odontogenic differentiation.
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影响因子：
2.6
作者：
Oka, Shoji;Oka, Kyoko;Chai, Yang
通讯作者：
Chai, Yang
影响因子：
64.8
作者：
Glinka, A;Wu, W;Niehrs, C
通讯作者：
Niehrs, C
影响因子：
4.6
作者：
Li, Jingyuan;Huang, Xiaofeng;Chai, Yang
通讯作者：
Chai, Yang
影响因子：
4.1
作者：
Cawthorn WP;Bree AJ;Yao Y;Du B;Hemati N;Martinez-Santibañez G;MacDougald OA
通讯作者：
MacDougald OA
影响因子：
2.7
作者：
Huang, Xiaofeng;Bringas, Pablo, Jr.;Slavkin, Harold C.;Chai, Yang
通讯作者：
Chai, Yang