Fate of HERS during tooth root development.
Fate of HERS during tooth root development.
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DOI：
10.1016/j.ydbio.2009.06.034
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发表时间：
2009-10-01
影响因子：
2.7
通讯作者：
Chai, Yang
中科院分区：
文献类型：
--
作者：
Huang, Xiaofeng;Bringas, Pablo, Jr.;Slavkin, Harold C.;Chai, Yang
关键词：
哺乳动物的牙根发育是在牙冠形成完成后开始的。先前的研究表明Hertwig's上皮根鞘（Hertwig's epithelial root sheath， HERS）在根发育中起重要作用，但其命运尚不清楚。为了研究HERS细胞在体内的形态命运和动态运动，我们生成了K14-Cre；R26R老鼠。在根形成的整个过程中，可以在根表面检测到HERS细胞，并且不会消失。大多数HERS细胞附着在牙骨质表面，其他细胞分离成为Malasez的上皮细胞。在牙泡细胞渗透到HERS网络接触牙本质之前，HERS细胞会将细胞外基质成分分泌到牙本质表面。HERS细胞也参与骨水泥的发育，并可能分化为骨水泥细胞。在根发育过程中，HERS细胞之间不中断，而是通过网络结构继续相互沟通。此外，HERS细胞与颅神经嵴来源的间质相互作用，指导根的发育。综上所述，HERS细胞网络对牙根发育至关重要。
Tooth root development begins after the completion of crown formation in mammals. Previous studies have shown that Hertwig's epithelial root sheath (HERS) plays an important role in root development, but the fate of HERS has remained unknown. In order to investigate the morphological fate and analyze the dynamic movement of HERS cells in vivo, we generated K14-Cre;R26R mice. HERS cells are detectable on the surface of the root throughout root formation and do not disappear. Most of the HERS cells are attached to the surface of the cementum, and others separate to become the epithelial rest of Malasez. HERS cells secrete extracellular matrix components onto the surface of the dentin before dental follicle cells penetrate the HERS network to contact dentin. HERS cells also participate in the cementum development and may differentiate into cementocytes. During root development, the HERS is not interrupted, and instead the HERS cells continue to communicate with each other through the network structure. Furthermore, HERS cells interact with cranial neural crest derived mesenchyme to guide root development. Taken together, the network of HERS cells is crucial for tooth root development.
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