Effect of early versus late onset mitral regurgitation on left ventricular remodeling in ischemic cardiomyopathy in an animal model.
Effect of early versus late onset mitral regurgitation on left ventricular remodeling in ischemic cardiomyopathy in an animal model.
复制标题
动物模型中早期与晚期发生的二尖瓣反流对缺血性心肌病左心室重构的影响。
DOI：
10.1016/j.jtcvs.2021.11.024
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发表时间：
2022-12
影响因子：
6
通讯作者：
Padala, Muralidhar
中科院分区：
文献类型：
--
作者：
Kono, Takanori;Onohara, Daisuke;Amedi, Alan;Corporan, Daniella;Padala, Muralidhar
关键词：
Patients surviving a myocardial infarction have progressive cardiac dysfunction and ventricular remodeling. Mitral regurgitation is often diagnosed in these patients, and is a risk factor that portends poor prognosis. Whether such post-infarction mitral regurgitation magnifies adverse left ventricular remodeling is unclear, which was studied in an animal model. Forty-one adult rats were induced with myocardial infarction by left coronary artery ligation and assigned to three groups: (group 1) myocardial infarction only; (group 2) myocardial infarction with severe mitral regurgitation introduced after 4 weeks; and (group 3) myocardial infarction with severe mitral regurgitation introduced after 10 weeks. Valve regurgitation was introduced by advancing a trans-apical, ultrasound guided needle into the mitral valve anterior leaflet. Animals were survived to 20 weeks from the index procedure, with biweekly cardiac ultrasound, and invasive hemodynamics and histology at termination. At 20 weeks, end diastolic volume was largest in the groups with mitral regurgitation, compared to the group without the valve lesion (group 1: 760.9±124.6μl, group 2: 958.0±115.1μl, group 3: 968.3±214.9μl). Similarly, end systolic volume was larger in groups with regurgitation (group 1: 431.2±152.6μl, group 2: 533.2±130.8μl, group 3: 533.1±177.5μl). In the infarction only group, left ventricular remodeling was maximal until 6 weeks and plateaued thereafter. In groups with mitral regurgitation, left ventricular remodeling was significantly elevated upon the onset of regurgitation and persisted. Mitral regurgitation is a potent driver of adverse cardiac remodeling after a myocardial infarction, irrespective of the timing of its onset.
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冠状动脉结构对大鼠冠状动脉结扎引起的心肌梗塞变异性的影响。
影响因子：
3.7
作者：
Kainuma S;Miyagawa S;Fukushima S;Tsuchimochi H;Sonobe T;Fujii Y;Pearson JT;Saito A;Harada A;Toda K;Shirai M;Sawa Y
通讯作者：
Sawa Y
DOI：
10.1038/nrcardio.2015.161
发表时间：
2015-12
期刊：
Nature reviews. Cardiology
影响因子：
--
作者：
Levine RA;Hagége AA;Judge DP;Padala M;Dal-Bianco JP;Aikawa E;Beaudoin J;Bischoff J;Bouatia-Naji N;Bruneval P;Butcher JT;Carpentier A;Chaput M;Chester AH;Clusel C;Delling FN;Dietz HC;Dina C;Durst R;Fernandez-Friera L;Handschumacher MD;Jensen MO;Jeunemaitre XP;Le Marec H;Le Tourneau T;Markwald RR;Mérot J;Messas E;Milan DP;Neri T;Norris RA;Peal D;Perrocheau M;Probst V;Pucéat M;Rosenthal N;Solis J;Schott JJ;Schwammenthal E;Slaugenhaupt SA;Song JK;Yacoub MH;Leducq Mitral Transatlantic Network
通讯作者：
Leducq Mitral Transatlantic Network
影响因子：
3.3
作者：
Hutchinson, Kirk R.;Guggilam, Anuradha;Lucchesi, Pamela A.
通讯作者：
Lucchesi, Pamela A.
影响因子：
37.8
作者：
Grigioni, F;Enriquez-Sarano, M;Tajik, AJ
通讯作者：
Tajik, AJ
影响因子：
37.8
作者：
WHITE, HD;NORRIS, RM;WILD, CJ
通讯作者：
WILD, CJ