Using multi-modal neuroimaging to characterise social brain specialisation in infants.
Using multi-modal neuroimaging to characterise social brain specialisation in infants.
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DOI：
10.7554/elife.84122
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发表时间：
2023-10-11
期刊：
影响因子：
7.7
通讯作者：
Jones EJH
中科院分区：
文献类型：
--
作者：
Siddiqui M;Pinti P;Brigadoi S;Lloyd-Fox S;Elwell CE;Johnson MH;Tachtsidis I;Jones EJH
成熟人类皮质的专门化区域功能在一定程度上是通过在早期发育过程中依赖经验的专门化而出现的。我们对婴儿大脑功能特化的现有理解是基于单一成像模式的证据，因此专注于对神经或血流动力学激活的空间或时间选择性的孤立估计，给出了一幅不完整的图景。我们推测，在广泛协调的生理反应中，更好地协调血流动力学和新陈代谢变化将支持功能专业化。为了使研究人员能够通过发育跟踪这一过程，我们开发了新的工具，允许同时测量清醒婴儿的协调神经活动(EEG)、代谢率和有氧血液供应(宽带近红外光谱)。在4到7个月大的婴儿中，我们使用这些新工具来表明，社交加工伴随着时间和空间上特定的时间-时间交界处耦合激活的增加，这是成人社交大脑的核心中枢区域。在非社会性加工过程中，同一区域的偶联激活减少，表明社会性加工是专一性的。高频大脑活动(贝塔和伽马)的耦合性最强，这与高频大脑活动的更大能量需求和更本地化的行动一致。同时多模式神经测量的发展将使未来的研究人员能够在理解大脑功能专门化方面开辟新的前景。
The specialised regional functionality of the mature human cortex partly emerges through experience-dependent specialisation during early development. Our existing understanding of functional specialisation in the infant brain is based on evidence from unitary imaging modalities and has thus focused on isolated estimates of spatial or temporal selectivity of neural or haemodynamic activation, giving an incomplete picture. We speculate that functional specialisation will be underpinned by better coordinated haemodynamic and metabolic changes in a broadly orchestrated physiological response. To enable researchers to track this process through development, we develop new tools that allow the simultaneous measurement of coordinated neural activity (EEG), metabolic rate, and oxygenated blood supply (broadband near-infrared spectroscopy) in the awake infant. In 4- to 7-month-old infants, we use these new tools to show that social processing is accompanied by spatially and temporally specific increases in coupled activation in the temporal-parietal junction, a core hub region of the adult social brain. During non-social processing, coupled activation decreased in the same region, indicating specificity to social processing. Coupling was strongest with high-frequency brain activity (beta and gamma), consistent with the greater energetic requirements and more localised action of high-frequency brain activity. The development of simultaneous multimodal neural measures will enable future researchers to open new vistas in understanding functional specialisation of the brain.
影响因子：
2.9
作者：
Siddiqui MF;Pinti P;Lloyd-Fox S;Jones EJH;Brigadoi S;Collins-Jones L;Tachtsidis I;Johnson MH;Elwell CE
通讯作者：
Elwell CE
影响因子：
4.8
作者：
Gao, Zaifeng;Goldstein, Abraham;Harpaz, Yuval;Hansel, Myriam;Zion-Golumbic, Elana;Bentin, Shlomo
通讯作者：
Bentin, Shlomo
影响因子：
3.7
作者：
Leech R;Scott G;Carhart-Harris R;Turkheimer F;Taylor-Robinson SD;Sharp DJ
通讯作者：
Sharp DJ