Regional Haemodynamic and Metabolic Coupling in Infants.
Regional Haemodynamic and Metabolic Coupling in Infants.
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DOI：
10.3389/fnhum.2021.780076
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发表时间：
2021
影响因子：
2.9
通讯作者：
Elwell CE
中科院分区：
文献类型：
--
作者：
Siddiqui MF;Pinti P;Lloyd-Fox S;Jones EJH;Brigadoi S;Collins-Jones L;Tachtsidis I;Johnson MH;Elwell CE
在神经发育过程中，脑功能的代谢途径在很大程度上仍未被探索，主要是由于缺乏用于清醒婴儿的可行技术。宽带近红外光谱（bNIRS）通过测量线粒体呼吸链酶细胞色素-c氧化酶（ΔoxCCO）氧化状态的变化以及血流动力学的变化，为探索脑能代谢与血氧合/血流动力学之间的关系提供了机会。我们使用bNIRS系统测量了42名年龄在4到7个月之间的正常发育婴儿在功能激活期间的ΔoxCCO和血流动力学。在社会和非社会视觉和听觉刺激下，在右半球颞叶、顶叶和中央皮层区域进行了birs测量。与非社会条件相比，ΔoxCCO和Δ[HbO2]在社会条件下都表现出更大的激活。血流动力学和代谢信号的整合揭示了刺激选择性皮质区域的网络，这在单个bNIRS信号的分析中并不明显。这些结果提供了婴儿功能激活期间脑代谢活动和血流动力学的第一个空间分辨测量。测量代谢和血流动力学的同步变化有可能揭示婴儿早期皮层特化的发展。
Metabolic pathways underlying brain function remain largely unexplored during neurodevelopment, predominantly due to the lack of feasible techniques for use with awake infants. Broadband near-infrared spectroscopy (bNIRS) provides the opportunity to explore the relationship between cerebral energy metabolism and blood oxygenation/haemodynamics through the measurement of changes in the oxidation state of mitochondrial respiratory chain enzyme cytochrome-c-oxidase (ΔoxCCO) alongside haemodynamic changes. We used a bNIRS system to measure ΔoxCCO and haemodynamics during functional activation in a group of 42 typically developing infants aged between 4 and 7 months. bNIRS measurements were made over the right hemisphere over temporal, parietal and central cortical regions, in response to social and non-social visual and auditory stimuli. Both ΔoxCCO and Δ[HbO2] displayed larger activation for the social condition in comparison to the non-social condition. Integration of haemodynamic and metabolic signals revealed networks of stimulus-selective cortical regions that were not apparent from analysis of the individual bNIRS signals. These results provide the first spatially resolved measures of cerebral metabolic activity alongside haemodynamics during functional activation in infants. Measuring synchronised changes in metabolism and haemodynamics have the potential for uncovering the development of cortical specialisation in early infancy.
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影响因子：
5.7
作者：
Arichi, Tomoki;Fagiolo, Gianlorenzo;Varela, Marta;Melendez-Calderon, Alejandro;Allievi, Alessandro;Merchant, Nazakat;Tusor, Nora;Counsell, Serena J.;Burdet, Etienne;Beckmann, Christian F.;Edwards, A. David
通讯作者：
Edwards, A. David
影响因子：
5.7
作者：
Bainbridge A;Tachtsidis I;Faulkner SD;Price D;Zhu T;Baer E;Broad KD;Thomas DL;Cady EB;Robertson NJ;Golay X
通讯作者：
Golay X
影响因子：
3.6
作者：
Franceschini, Maria Angela;Thaker, Sonal;Grant, P. Ellen
通讯作者：
Grant, P. Ellen
影响因子：
5.3
作者：
Bruckmaier, Merit;Tachtsidis, Ilias;Lavie, Nilli
通讯作者：
Lavie, Nilli
影响因子：
2.5
作者：
Born, AP;Rostrup, E;Lou, HC
通讯作者：
Lou, HC