Enhancement of pancreatic carcinogenesis by raw soy protein isolate: quantitative rat model and nutritional considerations.
Enhancement of pancreatic carcinogenesis by raw soy protein isolate: quantitative rat model and nutritional considerations.
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生大豆分离蛋白增强胰腺癌发生：定量大鼠模型和营养考虑。
DOI：
10.1007/978-1-4757-0022-0_5
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发表时间：
1986
影响因子：
--
通讯作者：
Roebuck,BD
中科院分区：
文献类型：
--
作者：
Roebuck,BD
含有大豆产品的食品已被证明可以改变几种实验动物胰腺的生化和生理状态。最近，这些产物被认为是导致胰腺肿瘤的一个因素。需要对可能的机制进行广泛的实验研究。综述了用于研究胰腺癌发生的大鼠/氮杂丝氨酸模型的实验细节。重点介绍了该模型的定量成分，以及该模型对致癌的两阶段(启动-促进)概念的适应性。对实验饮食的考虑给予了特别的关注。将这些概念应用于研究生大豆分离蛋白和加热大豆分离蛋白在添加和不添加高水平不饱和脂肪时的启动后效应。结果表明，生大豆分离株对氮杂丝氨酸诱导的胰腺癌小鼠的生长有促进作用，而高水平的不饱和脂肪对此影响不大。大豆分离物的影响可以通过加热来消除，但不饱和脂肪的影响不能通过类似的加热处理来消除。
Foods containing soybean products have been shown to modify the biochemical and physiological status of the pancreas of several species of experimental animals. Recently, these products have been implicated as a factor in the causation of pancreatic neoplasms. Extensive experimental studies into the possible mechanisms need to be undertaken. Experimental details of a rat/azaserine model for the study of pancreatic carcinogenesis are reviewed. Emphasis is given to the quantitative components of this model and the adaptation of this model to the two-stage (initiation-promotion) concept of carcinogenesis. Particular attention is devoted to considerations of the experimental diets. Application of these concepts to the study of the postinitiational effects of raw and heated soybean protein isolate with and without the addition of high levels of unsaturated fat were undertaken. The results indicate that raw soybean isolate enhanced the growth of azaserine-induced pancreatic foci; whereas, a high level of unsaturated fat had a minimal effect. The effects of the soybean isolate were abolished by heat treatments, but the effects of the unsaturated fat would not be expected to be abolished by similar treatment with heat.
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大鼠胰腺蛋白酶对膳食蛋白质、其水解产物和大豆胰蛋白酶抑制剂的反应。
DOI：
10.1093/jn/114.2.270
发表时间：
1984
期刊：
The Journal of nutrition
影响因子：
--
作者：
R. Temler;C. Dormond;E. Simon;B. Morel;C. Mettraux
通讯作者：
C. Mettraux
重氮丝氨酸和其他胰腺致癌物在啮齿动物胰腺中引起的病变。
影响因子：
10.4
作者：
Longnecker,DS
通讯作者：
Longnecker,DS
膳食脂肪增强叙利亚金仓鼠实验性胰腺癌的发生。
DOI：
10.1093/jnci/67.6.1327
发表时间：
1981
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
D. Birt;S. Salmasi;P. Pour
通讯作者：
P. Pour
不饱和脂肪促进重氮丝氨酸诱导的大鼠胰腺癌发生。
影响因子：
11.2
作者：
B. Roebuck;James D. Yager;Daniel S. Longnecker;S. Wilpone
通讯作者：
S. Wilpone
DOI：
--
发表时间：
1979
期刊：
Food and Cosmetics Toxicology
影响因子：
--
作者：
J. Fox;P. Thibert;D. Arnold;D. Krewski;H. Grice
通讯作者：
H. Grice