Inhibition of tumor growth by elimination of granulocytes.
Inhibition of tumor growth by elimination of granulocytes.
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DOI：
10.1084/jem.181.1.435
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发表时间：
1995-01-01
影响因子：
15.3
通讯作者：
Schreiber, Hans
中科院分区：
文献类型：
--
作者：
Pekarek, Lisa A.;Starr, Barbara A.;Toledano, Alicia Y.;Schreiber, Hans
正如对许多类型的癌症所观察到的那样，紫外线诱导的肿瘤的遗传变体通常比亲本肿瘤更具侵略性。一些变体的侵袭性生长是由于T细胞识别的肿瘤特异性抗原的丢失;然而，其他变体保留了这样的抗原。我们分析了抗原保留变体，发现变体肿瘤细胞在体外以与亲本肿瘤细胞相同的速率生长，但在T细胞缺陷宿主中比亲本细胞生长更快。通过从肿瘤诱导的白细胞释放的因子和几种确定的生长因子在体外刺激变体细胞的生长。此外，变异癌细胞实际上比亲本细胞在体外吸引更多的白细胞。此外，在裸鼠体内通过特异性抗粒细胞抗体消除粒细胞抑制了变异癌的生长，表明这种肿瘤需要粒细胞快速生长。
As observed for many types of cancers, heritable variants of ultraviolet light-induced tumors often grow more aggressively than the parental tumors. The aggressive growth of some variants is due to the loss of a T cell-recognized tumor-specific antigen; however, other variants retain such antigens. We have analyzed an antigen retention variant and found that the variant tumor cells grow at the same rate as the parental tumor cells in vitro, but grew more rapidly than the parental cells in the T cell-deficient host. The growth of the variant cells was stimulated in vitro by factors released from tumor-induced leukocytes and by several defined growth factors. In addition, the variant cancer cells actually attracted more leukocytes in vitro than the parental cells. Furthermore, elimination of granulocytes in vivo in nude mice by a specific antigranulocyte antibody inhibited the growth of the variant cancer, indicating that this tumor requires granulocytes for rapid growth.
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DOI：
10.1073/pnas.88.14.6028
发表时间：
1991-07-01
影响因子：
11.1
作者：
CORNIL, I;THEODORESCU, D;KERBEL, RS
通讯作者：
KERBEL, RS
DOI：
10.1093/jnci/53.5.1333
发表时间：
1974-01-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
KRIPKE, ML
通讯作者：
KRIPKE, ML
DOI：
10.1073/pnas.89.13.6197
发表时间：
1992-07-01
影响因子：
11.1
作者：
ROSSI, MC;ZETTER, BR
通讯作者：
ZETTER, BR
DOI：
10.1016/0006-291x(85)90614-x
发表时间：
1985-01-01
影响因子：
3.1
作者：
BAIRD, A;MORMEDE, P;BOHLEN, P
通讯作者：
BOHLEN, P
影响因子：
15.9
作者：
ODONNELLTORMEY, J;DEBOER, CJ;NATHAN, CF
通讯作者：
NATHAN, CF