Photothermal nanoagent for anti-inflammation through macrophage repolarization following antibacterial therapy
Photothermal nanoagent for anti-inflammation through macrophage repolarization following antibacterial therapy
复制标题
光热纳米剂通过抗菌治疗后巨噬细胞复极化来抗炎
DOI：
10.1016/j.eurpolymj.2023.111840
复制
发表时间：
2023-03
影响因子：
6
通讯作者：
Yun Liu
中科院分区：
文献类型：
--
作者：
Yueying Xu;Yanjun Cai;Yu Xia;Quanxin Wu;Mingen Li;Ning Guo;Yingfeng Tu;Bin Yang;Yun Liu
由于细菌耐药性被忽视，光热疗法(PTT)在细菌感染方面得到了广泛的研究。然而，很少有研究主要集中在PTT后同时使用光热制剂(PTA)进行抗炎治疗。在这里，我们以牛血清白蛋白为纳米反应器和胶体稳定剂，通过Fe3+与表没食子儿茶素没食子酸酯(EGCG)的自组装制备了纳米PTA(BSA@MPN)。接下来，我们评估了其光热和清除活性氧自由基(ROS)的能力。此外，我们还分别通过体外抑菌和细胞实验评价了其抗菌和抗炎能力。最后对其体内杀菌和抗炎作用进行了检测。首先，由于金属-苯酚网络(MPN)固有的光热能力，.BSA@MPN表现出良好的光热性能。因此，BSA@MPN在体外和体内都表现出了良好的抗菌能力，而且由于EGCG对ROS的清除作用，BSA@MPN具有优异的抗氧化性能。因此，通过释放EGCG促进促炎(M1)巨噬细胞向抗炎(M2)巨噬细胞的复极化，该纳米制剂在体外和体内都表现出非凡的抗炎效率。研究结果表明，所制备的纳米制剂在未来的临床应用中具有巨大的潜力用于联合抗菌和抗炎治疗。
Owing to the ignorable bacterial resistance, photothermal therapy (PTT) has been widely studied for bacterial.infection. However, few research efforts have focused primarily on the simultaneous utilization of photothermal.agents (PTAs) for anti-inflammatory therapy following PTT. Here, we developed a nano-sized PTA (BSA@MPN).through the self-assembly of Fe3+ and epigallocatechin-3-gallate (EGCG) by using BSA as the nanoreactor and.colloidal stabilizer. Next, we assessed its photothermal and reactive oxygen species (ROS) scavenging properties..In addition, we evaluated its antibacterial and anti-inflammatory abilities through in vitro antibacterial and.cellular assays, respectively. Finally, we tested its in vivo sterilization and anti-inflammatory effects. Firstly,.BSA@MPN displayed good photothermal capacity due to the inherent photothermal ability of metal-phenolic.networks (MPNs). Consequently, BSA@MPN showed excellent both in vitro and in vivo antibacterial capacities..Moreover, BSA@MPN exhibited outstanding anti-oxidative property owing to ROS scavenging effect of EGCG. As.a result, it presented extraordinary both in vitro and in vivo anti-inflammatory efficiencies through promoting the.repolarization of pro-inflammatory (M1) macrophages to anti-inflammatory (M2) macrophages with the released.EGCG. The research findings indicated that the prepared nanoagent has great potential to be used for combined.antibacterial and anti-inflammatory treatments in future clinical applications.
登录
查看更多内容
影响因子：
15.1
作者：
Yang Wu;Guiyun Deng;Zhiyong Song;Kai Zhang;Jiamin Deng;Kai Jiang;Heyou Han
通讯作者：
Yang Wu;Guiyun Deng;Zhiyong Song;Kai Zhang;Jiamin Deng;Kai Jiang;Heyou Han
影响因子：
15.1
作者：
Li, Yue;Miao, Yong;Yang, Lunan;Zhao, Yitao;Wu, Keke;Lu, Zhihui;Hu, Zhiqi;Guo, Jinshan
通讯作者：
Guo, Jinshan
基于石墨烯的双靶点平台，用于协同化学光热疗法对抗多重耐药革兰氏阴性菌及其生物膜
影响因子：
15.1
作者：
Wang He;Zhao Baohua;Dong Wenjing;Zhong Yuan;Zhang Xiaorong;Gong Yali;Zhan Rixing;Xing Malcolm;Zhang Jianxiang;Luo Gaoxing;Qian Wei
通讯作者：
Qian Wei
影响因子：
19
作者：
Xiangchun Zhang;Zhichao Zhang;Qingming Shu;Chao Xu;Qinqin Zheng;Zhao Guo;Chen Wang;Zhenxia Hao;Xin Liu;Guoqing Wang;Wangjun Yan;Hongping Chen;Chengyin Lu
通讯作者：
Xiangchun Zhang;Zhichao Zhang;Qingming Shu;Chao Xu;Qinqin Zheng;Zhao Guo;Chen Wang;Zhenxia Hao;Xin Liu;Guoqing Wang;Wangjun Yan;Hongping Chen;Chengyin Lu
通过减小 4,6-二氨基-2-嘧啶硫醇修饰的金纳米颗粒的尺寸来激活其抗菌效果。
DOI：
10.1002/anie.202008584
发表时间：
2020
期刊：
Angewandte Chemie International Edition
影响因子：
--
作者：
Yangzhouyun Xie;Junchuang Yang;Jiangjiang Zhang;Wenfu Zheng;Xingyu Jiang
通讯作者：
Xingyu Jiang