Herpesvirus transport to the nervous system and back again.

Herpesvirus transport to the nervous system and back again.
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DOI:
10.1146/annurev-micro-092611-150051
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发表时间:
2012
影响因子:
10.5
通讯作者:
Smith G
Smith G
中科院分区:
生物学1区
文献类型:
--
作者:
Smith G

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单纯疱疹病毒、水痘带状疱疹病毒和伪狂犬病毒是疱疹病毒科甲型疱疹病毒亚家族的嗜神经病原体。这些病毒有效地侵入周围神经系统,并在外周神经节的神经元中建立终身潜伏。原发性和复发性感染使病毒颗粒在神经元和它们支配的外周组织之间循环。这一显著的感染周期是本综述的主题。此外,这些病毒引起的感染的一些显著特征是根据它们潜在的相似性进行评估的。
Herpes simplex virus, varicella zoster virus, and pseudorabies virus are neurotropic pathogens of the Alphaherpesvirinae subfamily of the Herpesviridae. These viruses efficiently invade the peripheral nervous system and establish lifelong latency in neurons resident in peripheral ganglia. Primary and recurrent infections cycle virus particles between neurons and the peripheral tissues they innervate. This remarkable cycle of infection is the topic of this review. In addition, some of the distinguishing hallmarks of the infections caused by these viruses are evaluated in terms of their underlying similarities.
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