Spinal cord normalization in multiple sclerosis.
Spinal cord normalization in multiple sclerosis.
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DOI：
10.1111/jon.12097
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Reich DS
中科院分区：
文献类型：
--
作者：
Oh J;Seigo M;Saidha S;Sotirchos E;Zackowski K;Chen M;Prince J;Diener-West M;Calabresi PA;Reich DS
脊髓（SC）病理在多发性硬化（MS）中很常见，并且SC萎缩的测量越来越多地被使用。标准化减少了与疾病无关的结构测量的生物学变化，但SC体积（SCV）标准化的最佳参数仍不清楚。使用各种标准化因素和临床措施，我们评估了SCV正常化检测组间差异和澄清MS的临床放射学相关性的影响。在133例MS病例和11例健康对照（HC）中进行了3 T颈部SC-MRI。临床评估包括：扩展残疾状态量表（EDSS）、MS功能复合量表（MSFC）、定量髋关节屈曲强度（“强度”）和振动感觉阈值（“振动”）。测量C3-C4之间的SCV，并根据受试者身高、SC长度和颅内体积（ICV）进行单独标准化。在原始SCV和通过身高和长度标准化后，存在组间差异（MS vs. HC;进行性vs.复发性MS亚型，p<0.05）。临床指标与原始SCV之间存在相关性（EDSS：r=-0.20; MSFC：r=0.16;力量：r=0.35;振动：r=-0.19）。相关性随着长度（EDSS：r=-0.43; MSFC：r=0.33;强度：r= 0.38;振动：r=-0.40）和身高（EDSS：r=-0.26; MSFC：r=0.28;强度：r= 0.22;振动：r=-0.29）的归一化而持续增强，但随着ICV的归一化而减弱（EDSS：r=-0.23; MSFC：r=-0.10;强度：r=0.23;振动：r=-0.35）。在复发性MS中，长度标准化允许统计检测与原始SCV不明显的相关性。SCV长度标准化提高了检测组差异的能力，加强了临床-放射学相关性，并且在MS中的细微疾病相关SC萎缩的设置中特别相关。SCV长度标准化可以增强SC萎缩测量的临床实用性。
Spinal cord(SC) pathology is common in multiple sclerosis(MS), and measures of SC-atrophy are increasingly utilized. Normalization reduces biological variation of structural measurements unrelated to disease, but optimal parameters for SC volume(SCV)-normalization remain unclear. Using a variety of normalization factors and clinical measures, we assessed the effect of SCV-normalization on detecting group differences and clarifying clinical-radiological correlations in MS. 3T cervical SC-MRI was performed in 133 MS cases and 11 healthy controls(HC). Clinical assessment included:expanded disability status scale(EDSS), MS functional composite(MSFC), quantitative hip-flexion strength(“strength”), and vibration sensation threshold(“vibration”). SCV between C3-C4 was measured and normalized individually by:subject height, SC-length, and intracranial volume(ICV). There were group differences in raw-SCV and after normalization by height and length(MS vs. HC; progressive vs. relapsing MS-subtypes, p<0.05). There were correlations between clinical measures and raw-SCV(EDSS:r=−0.20; MSFC:r=0.16; strength:r=0.35; vibration:r=−0.19). Correlations consistently strengthened with normalization by length(EDSS:r=−0.43; MSFC:r=0.33; strength:r=0.38; vibration:r=−0.40) and height(EDSS:r=−0.26; MSFC:r=0.28; strength:r=0.22; vibration:r=−0.29), but diminished with normalization by ICV(EDSS:r=−0.23; MSFC:r=−0.10; strength:r=0.23; vibration:r=−0.35). In relapsing MS, normalization by length allowed statistical detection of correlations that were not apparent with raw-SCV. SCV-normalization by length improves the ability to detect group differences, strengthens clinical-radiological correlations, and is particularly relevant in settings of subtle disease-related SC-atrophy in MS. SCV-normalization by length may enhance the clinical utility of measures of SC-atrophy.
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多发性硬化症中脊髓中感觉运动功能的多参数MRI相关。
DOI：
10.1177/1352458512456614
发表时间：
2013-04
期刊：
Multiple sclerosis (Houndmills, Basingstoke, England)
影响因子：
--
作者：
Oh J;Zackowski K;Chen M;Newsome S;Saidha S;Smith SA;Diener-West M;Prince J;Jones CK;Van Zijl PC;Calabresi PA;Reich DS
通讯作者：
Reich DS
影响因子：
4.4
作者：
Mann, Ranbir S.;Constantinescu, Cris S.;Tench, Christopher R.
通讯作者：
Tench, Christopher R.
影响因子：
2.4
作者：
Healy, Brian C.;Arora, Ashish;Bakshi, Rohit
通讯作者：
Bakshi, Rohit
影响因子：
2.8
作者：
Zivadinov, R;Locatelli, L;Zorzon, M
通讯作者：
Zorzon, M
影响因子：
11.2
作者：
Polman CH;Reingold SC;Banwell B;Clanet M;Cohen JA;Filippi M;Fujihara K;Havrdova E;Hutchinson M;Kappos L;Lublin FD;Montalban X;O'Connor P;Sandberg-Wollheim M;Thompson AJ;Waubant E;Weinshenker B;Wolinsky JS
通讯作者：
Wolinsky JS