Estrogen: a master regulator of bioenergetic systems in the brain and body.
Estrogen: a master regulator of bioenergetic systems in the brain and body.
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DOI：
10.1016/j.yfrne.2013.08.001
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发表时间：
2014-01
影响因子：
7.4
通讯作者：
Brinton, Roberta Diaz
中科院分区：
文献类型：
--
作者：
Rettberg, Jamaica R.;Yao, Jia;Brinton, Roberta Diaz
关键词：
雌激素是女性大脑和身体代谢系统的基本调节剂。在脑内，雌激素调节葡萄糖转运、有氧糖酵解和线粒体功能以产生ATP。在体内，雌激素可以预防肥胖、胰岛素抵抗和II型糖尿病，并调节能量摄入和消耗。在绝经期间，循环雌激素的下降与大脑生物能量学的下降一致，并向代谢受损的表型转变。对雌激素损失的补偿性生物能量适应或缺乏可能决定晚发性阿尔茨海默病的风险。雌激素协调大脑和身体代谢，使得外周代谢状态可以指示大脑的生物能量状态。通过生成包括绝经期发生的外周代谢变化的生物标志物谱，可以创建脑生物能量学降低和认知能力下降的个体风险谱。生物标志物谱可以识别处于风险中的妇女，同时也可以作为激素治疗或其他预防性干预措施的有效性指标。
Estrogen is a fundamental regulator of the metabolic system of the female brain and body. Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial function to generate ATP. In the body, estrogen protects against adiposity, insulin resistance, and type II diabetes, and regulates energy intake and expenditure. During menopause, decline in circulating estrogen is coincident with decline in brain bioenergetics and shift towards a metabolically compromised phenotype. Compensatory bioenergetic adaptations, or lack thereof, to estrogen loss could determine risk of late-onset Alzheimer’s disease. Estrogen coordinates brain and body metabolism, such that peripheral metabolic state can indicate bioenergetic status of the brain. By generating biomarker profiles that encompass peripheral metabolic changes occurring with menopause, individual risk profiles for decreased brain bioenergetics and cognitive decline can be created. Biomarker profiles could identify women at risk while also serving as indicators of efficacy of hormone therapy or other preventative interventions.
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