Roles of dopamine and glutamate co-release in the nucleus accumbens in mediating the actions of drugs of abuse.
Roles of dopamine and glutamate co-release in the nucleus accumbens in mediating the actions of drugs of abuse.
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DOI：
10.1111/febs.15496
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Freyberg Z
中科院分区：
文献类型：
--
作者：
Buck SA;Torregrossa MM;Logan RW;Freyberg Z
腹侧被盖区多巴胺（DA）神经元向伏隔核内侧壳的投射越来越多地被认为是物质使用障碍（SUD）发展所涉及的行为和生理变化的组成部分。最近，发现许多这些投射多巴胺的核神经元也释放神经递质谷氨酸。这种从DA神经元共同释放的谷氨酸在介导药物滥用对成瘾相关行为的影响中至关重要。多巴胺/谷氨酸共释放在促成SUD中的潜在作用机制尚不清楚。然而，一个重要的线索可能涉及谷氨酸的能力，以加强加载DA到突触囊泡内的终端在延髓核响应于药物诱导的神经元活动的升高，使更强大的DA刺激后释放。在这里，我们总结了滥用药物，特别是可卡因，阿片类药物和酒精，改变DA释放在延髓核内侧壳，研究DA/谷氨酸共同释放在介导这些影响的潜在作用，并讨论未来的方向，进一步研究这些机制。
Projections of ventral tegmental area dopamine (DA) neurons to the medial shell of the nucleus accumbens have been increasingly implicated as integral to the behavioral and physiological changes involved in the development of substance use disorders (SUDs). Recently, many of these nucleus accumbens-projecting DA neurons were found to also release the neurotransmitter glutamate. This glutamate co-release from DA neurons is critical in mediating the effect of drugs of abuse on addiction-related behaviors. Potential mechanisms underlying the role(s) of dopamine/glutamate co-release in contributing to SUDs are unclear. Nevertheless, an important clue may relate to glutamate’s ability to potentiate loading of DA into synaptic vesicles within terminals in the nucleus accumbens in response to drug-induced elevations in neuronal activity, enabling a more robust release of DA after stimulation. Here, we summarize how drugs of abuse, particularly cocaine, opioids and alcohol, alter DA release in the nucleus accumbens medial shell, examine the potential role of DA/glutamate co-release in mediating these effects, and discuss future directions for further investigating these mechanisms.
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影响因子：
16.2
作者：
Chuhma N;Mingote S;Moore H;Rayport S
通讯作者：
Rayport S
与奖励相关行为中的多巴胺信号传导。
影响因子：
3.5
作者：
Baik JH
通讯作者：
Baik JH
影响因子：
4.3
作者：
Anderson RI;Becker HC;Adams BL;Jesudason CD;Rorick-Kehn LM
通讯作者：
Rorick-Kehn LM
DOI：
10.1038/npp.2009.187
发表时间：
2010-02
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
25
作者：
Bossert, Jennifer M.;Stern, Anna L.;Theberge, Florence R. M.;Cifani, Carlo;Koya, Eisuke;Hope, Bruce T.;Shaham, Yavin
通讯作者：
Shaham, Yavin