Gut Microbiota: An Integral Moderator in Health and Disease.
Gut Microbiota: An Integral Moderator in Health and Disease.
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肠道微生物群：健康和疾病的整体调节因素
DOI：
10.3389/fmicb.2018.00151
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发表时间：
2018
影响因子：
5.2
通讯作者：
Wang YD
中科院分区：
文献类型：
--
作者：
Feng Q;Chen WD;Wang YD
肠道菌群是肠道微生态的主要成员，是健康和疾病的重要介质。肠道微生物群与体内的各种器官和系统相互作用，包括脑、肺、肝、骨、心血管系统等。微生物群衍生的代谢物，如短链脂肪酸（SCFA）丁酸盐，是连接肠道微生物群和生理学的主要信号。最近，肠道微生物群已被确定为许多疾病的起源，通过影响相关的细胞信号通路，如结直肠癌中的WNT/β-连环蛋白通路和中枢神经系统中的T细胞受体信号。此外，一些microRNA通过干预肠道微生物群参与信号网络。肠道微生物群和miRNA之间的相互作用在血管功能障碍和肝细胞癌（HCC）中起着至关重要的作用。在这篇综述中，我们将报告和讨论有关肠道微生物群和身体器官之间的串扰以及肠道微生物群和miRNA如何相互调节，同时通过基因，蛋白质或代谢产物影响宿主的最新发现。
The gut microbiota, as the main member in gut microecology, is an essential mediator in health and disease. The gut microbiota interacts with various organs and systems in the body, including brain, lung, liver, bone, cardiovascular system, and others. Microbiota-derived metabolites such as the short chain fatty acid (SCFA) butyrate are primary signals, which link the gut microbiota and physiology. Recently, the gut microbiota has been identified as the origin of a number of diseases by influencing the related cell signaling pathways such as WNT/beta-catenin pathway in colorectal cancer and T cell receptor signaling in the central nervous system. Moreover, several microRNAs participate in signaling networks through the intervention of the gut microbiota. The interaction between the gut microbiota and miRNAs plays a crucial role in vascular dysfunction and hepatocellular carcinoma (HCC). In this review, we will report and discuss recent findings about the crosstalk between the gut microbiota and physical organs and how the gut microbiota and miRNAs regulate each other while influencing the host via genes, proteins, or metabolites.
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影响因子：
5.6
作者：
Britton, Robert A.;Irwin, Regina;Quach, Darin;Schaefer, Laura;Zhang, Jing;Lee, Taehyung;Parameswaran, Narayanan;McCabe, Laura R.
通讯作者：
McCabe, Laura R.
影响因子：
29
作者：
Donohoe DR;Garge N;Zhang X;Sun W;O'Connell TM;Bunger MK;Bultman SJ
通讯作者：
Bultman SJ
影响因子：
17.1
作者：
Gray J;Oehrle K;Worthen G;Alenghat T;Whitsett J;Deshmukh H
通讯作者：
Deshmukh H
影响因子：
17.1
作者：
Arrieta, Marie-Claire;Stiemsma, Leah T.;Finlay, B. Brett
通讯作者：
Finlay, B. Brett
影响因子：
7.3
作者：
Gray LE;O'Hely M;Ranganathan S;Sly PD;Vuillermin P
通讯作者：
Vuillermin P