Development of the ocellar visual system in Drosophila melanogaster.
Development of the ocellar visual system in Drosophila melanogaster.
复制标题
果蝇眼视觉系统的发育。
DOI：
10.1111/febs.16468
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发表时间：
2022-12
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
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果蝇（Drosophila melanogaster）的成年视觉系统包含7只眼睛——两只复眼，一对Hofbauer - Buchner眼和3只单眼。每种类型的眼睛都在视觉和/或昼夜节律行为中发挥着特殊而重要的作用。因此，了解每一个是如何指定，模式和连接对视觉生物学家是至关重要的。由于果蝇可以被大量的遗传和分子工具操纵，它的发展是最好的和研究最多的模型系统之一。经过一个多世纪的实验研究，我们对每一种眼睛类型是如何指定和图案的理解是非常不平衡的。复眼已经成为数千项研究的主题；因此，我们对其发展的认识是最深的。相比之下，我们对另外两种视觉系统的规范和模式知之甚少。在这篇观点文章中，我们将描述关于果蝇的功能和发育的已知情况。眼是一种视觉器官，与复眼和Hofbauer - Buchner眼一起，负责各种视觉和昼夜节律行为。在果蝇（Drosophila melanogaster）中，已经发现了一些功能缺失突变，这些突变会对卵细胞的规格、数量、生长、间距和位置产生负面影响。这些突变体提供了对控制这些重要视觉器官发育的基因调控网络的关键见解。
The adult visual system of the fruit fly, Drosophila melanogaster, contains seven eyes—two compound eyes, a pair of Hofbauer‐Buchner eyelets, and three ocelli. Each of these eye types has a specialized and essential role to play in visual and/or circadian behavior. As such, understanding how each is specified, patterned, and wired is of primary importance to vision biologists. Since the fruit fly is amenable to manipulation by an enormous array of genetic and molecular tools, its development is one of the best and most studied model systems. After more than a century of experimental investigations, our understanding of how each eye type is specified and patterned is grossly uneven. The compound eye has been the subject of several thousand studies; thus, our knowledge of its development is the deepest. By comparison, very little is known about the specification and patterning of the other two visual systems. In this Viewpoint article, we will describe what is known about the function and development of the Drosophila ocelli. The ocelli are visual organs that, along with the compound eyes and Hofbauer‐Buchner eyelets, are responsible for a variety of visual and circadian behaviors. In the fruit fly, Drosophila melanogaster, a number of loss‐of‐function mutants have been identified that negatively impact the specification, number, growth, spacing, and positioning of the ocelli. These mutants provide key insights into the gene regulatory networks that control the development of these important visual organs.
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