Thyroxine therapy ameliorates serum levels of eicosanoids in Chinese subclinical hypothyroidism patients
Thyroxine therapy ameliorates serum levels of eicosanoids in Chinese subclinical hypothyroidism patients
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甲状腺素治疗可改善中国亚临床甲状腺功能减退症患者的类二十烷酸血清水平。
DOI：
10.1038/aps.2015.149
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发表时间：
2016-03
影响因子：
8.2
通讯作者：
Zhao Jia-jun
中科院分区：
文献类型：
--
作者：
Zhang Yan;Zhang Bing-chang;Xu Jin;Zhao Meng;Wang Zhe;Song Yong-feng;Zhang Hai-qing;Gao Ling;Zhang Qun-ye;Zhao Jia-jun
目的：磷脂衍生的二十烷类化合物在炎症反应中起关键作用。然而，亚临床甲状腺功能减退（SH）患者血清二十烷类蛋白的特征以及甲状腺素替代治疗（TRT）对这些二十烷类蛋白的影响尚不清楚。许多研究表明，TSH调节脂质代谢。由于磷脂衍生的类二十烷酸在氧化应激、免疫功能和炎症过程中起关键作用，因此有必要探讨SH患者血清类二十烷酸的特征以及甲状腺素替代治疗（TRT）对类二十烷酸的影响。方法：共招募50例中国SH患者和22名健康志愿者。SH患者接受TRT治疗（TSH≤10.0 mIU/L、TSH≤10.0 mIU/L患者分别给予L- t4、25、50 mcg/d），疗程3个月。采用LC-MS和临床生化分析血清主要类二十烷酸和cPLA2水平。结果：SH患者血清cPLA2、20烷类化合物（8-isoPGF2a、11-dehydroTXB2和12-HETE）和11-dehydroTXB2/6- keto - pgf1a水平显著升高。血清TSH水平与cPLA2 （r=+ 0.65）、11-dehydroTXB2 （r=+ 0.32）、11-dehydroTXB2/6- keto - pgf1a水平显著相关（r=+ 0.37）。经3个月TRT治疗后，SH患者血清TSH、cPLA2及上述二十烷类化合物水平均显著降低。结论：中国SH患者类二十烷酸代谢明显改变，TRT可改善血清类二十烷酸水平异常。
Aim:The eicosanoids derived from phospholipids play key roles in inflammation. However, the profiles of serum eicosanoids in subclinical hypothyroidism (SH) patients and the effects of thyroxine replacement therapy (TRT) on these eicosanoids remain unclear. Many studies show that TSH regulates lipid metabolism. As eicosanoids derived from phospholipids play key roles in oxidative stress and immune function and inflammatory process, it was necessary to explore the profiles of serum eicosanoids in SH patients and the effects of thyroxine replacement therapy (TRT) on the eicosanoids.Methods:A total of 50 Chinese SH patients and 22 healthy volunteers were recruited. SH patients received TRT (L-T4, 25 and 50 mcg/d for patients with TSH≤ 10.0 mIU/L and TSH> 10.0 mIU/L, respectively) for 3 months. Serum levels of major eicosanoids and cPLA2 were analyzed using LC-MS and clinical biochemical assays.Results:The serum levels of cPLA2, eicosanoids (8-isoPGF2a, 11-dehydroTXB2 and 12-HETE) and 11-dehydroTXB2/6-Keto-PGF1a were significantly elevated in SH patients. The serum TSH levels were significantly correlated with the levels of cPLA2 (r=+ 0.65), 11-dehydroTXB2 (r=+ 0.32) and 11-dehydroTXB2/6-Keto-PGF1a (r=+ 0.37). After 3-month TRT, the serum levels of TSH, cPLA2 and the above-mentioned eicosanoids in SH patients were significantly decreased.Conclusion:The metabolism of eicosanoids is significantly altered in Chinese SH patients, and TRT can ameliorate the abnormalities of serum eicosanoid levels.
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影响因子：
15.9
作者：
Kobayashi, T;Tahara, Y;Narumiya, S
通讯作者：
Narumiya, S
DOI：
10.1155/2013/856017
发表时间：
2013-09-23
期刊：
ISRN endocrinology
影响因子：
--
作者：
Annerbo S;Lökk J
通讯作者：
Lökk J
亚临床甲状腺功能减退症患者的脂质参数改变。
影响因子：
2.1
作者：
Laway BA;War FA;Shah S;Misgar RA;Kumar Kotwal S
通讯作者：
Kumar Kotwal S
影响因子：
1.9
作者：
Kostapanos, Michael S.;Spyrou, Athanasia T.;Liberopoulos, Evangelos N.
通讯作者：
Liberopoulos, Evangelos N.
影响因子：
1.9
作者：
Demartini, Benedetta;Ranieri, Rebecca;Gambini, Orsola
通讯作者：
Gambini, Orsola