Serum vaccine antibody concentrations in children exposed to perfluorinated compounds.
Serum vaccine antibody concentrations in children exposed to perfluorinated compounds.
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DOI：
10.1001/jama.2011.2034
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发表时间：
2012-01-25
影响因子：
120.7
通讯作者：
Heilmann, Carsten
中科院分区：
文献类型：
--
作者：
Grandjean, Philippe;Andersen, Elisabeth Wreford;Budtz-Jorgensen, Esben;Nielsen, Flemming;Molbak, Kare;Weihe, Pal;Heilmann, Carsten
全氟化合物（PFCs）已成为重要的食品污染物。在啮齿类动物模型中，当血清浓度与美国人群中的浓度相似时，它们会导致免疫抑制，但人们对全氟化碳暴露的不良健康影响知之甚少。确定PFC暴露是否与儿童期疫苗接种的抗体应答相关。法罗群岛国立医院出生队列的前瞻性研究。在1997-2000年期间，共招募了656名连续的单胎分娩，587名参与了到2008年的随访。5岁和7岁儿童破伤风和白喉类毒素血清抗体浓度。与美国先前研究的结果类似，血清浓度最高的全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）。在孕妇妊娠血清中的全氟辛烷磺酸中，全氟辛烷磺酸与5岁时的抗体浓度呈最强的负相关性，接触浓度增加2倍，白喉抗体浓度的差异为-39%（95%置信区间，-55%至-17%）。5岁儿童血清中的全氟辛烷磺酸与抗体水平呈一致负相关，特别是在7岁儿童中，但全氟辛烷磺酸暴露后的破伤风抗体水平在统计学上并不显著。在结构方程模型中，儿童血清中主要PFC浓度增加2倍与总体抗体浓度的差异为−49%（95%CI，−67%至−23%）相关。5岁时全氟辛烷磺酸和全氟辛酸浓度增加2倍，7岁时破伤风和白喉抗体低于0.1 IU/mL临床保护水平的优势比为2.38（95% CI，0.89至6.35）至4.20（95% CI，1.54至11.44）。在5岁和7岁的儿童中，暴露于PFCs的增加与对常规儿童免疫接种的体液免疫应答降低有关。
Perfluorinated compounds (PFCs) have emerged as important food contaminants. They cause immune suppression in a rodent model at serum concentrations similar to those occurring in the US population, but adverse health effects of PFC exposure are poorly understood. To determine whether PFC exposure is associated with antibody response to childhood vaccinations. Prospective study of a birth cohort from the National Hospital in the Faroe Islands. A total of 656 consecutive singleton births were recruited during 1997-2000, and 587 participated in follow-up through 2008. Serum antibody concentrations against tetanus and diphtheria toxoids at ages 5 and 7 years. Similar to results of prior studies in the United States, the PFCs with the highest serum concentrations were perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). Among PFCs in maternal pregnancy serum, PFOS showed the strongest negative correlations with antibody concentrations at age 5 years, for which a 2-fold greater concentration of exposure was associated with a difference of −39% (95% CI, −55% to −17%) in the diphtheria antibody concentration. PFCs in the child’s serum at age 5 years showed uniformly negative associations with antibody levels, especially at age 7 years, except that the tetanus antibody level following PFOS exposure was not statistically significant. In a structural equation model, a 2-fold greater concentration of major PFCs in child serum was associated with a difference of −49% (95% CI, −67% to −23%) in the overall antibody concentration. A 2-fold increase in PFOS and PFOA concentrations at age 5 years was associated with odds ratios between 2.38 (95% CI, 0.89 to 6.35) and 4.20 (95% CI, 1.54 to 11.44) for falling below a clinically protective level of 0.1 IU/mL for tetanus and diphtheria antibodies at age 7 years. Elevated exposures to PFCs were associated with reduced humoral immune response to routine childhood immunizations in children aged 5 and 7 years.
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影响因子：
15.8
作者：
Heilmann C;Grandjean P;Weihe P;Nielsen F;Budtz-Jørgensen E
通讯作者：
Budtz-Jørgensen E
影响因子：
11.4
作者：
Kato, Kayoko;Calafat, Antonia M.;Needham, Larry L.
通讯作者：
Needham, Larry L.
影响因子：
3.3
作者：
Dietert, Rodney R.
通讯作者：
Dietert, Rodney R.
DOI：
10.1016/0092-1157(88)90017-0
发表时间：
1988-01-01
期刊：
JOURNAL OF BIOLOGICAL STANDARDIZATION
影响因子：
--
作者：
HENDRIKSEN, CFM;VANDERGUN, JW;KREEFTENBERG, JG
通讯作者：
KREEFTENBERG, JG
细胞因子和 MAPK 信号通路的改变与全氟壬酸的免疫毒性作用有关
影响因子：
3.8
作者：
Fang, Xuemei;Feng, Yixing;Dai, Jiayin
通讯作者：
Dai, Jiayin