Factors shaping the adaptive landscape for arboviruses: implications for the emergence of disease.
Factors shaping the adaptive landscape for arboviruses: implications for the emergence of disease.
复制标题
DOI：
10.2217/fmb.12.139
复制
发表时间：
2013-02
影响因子：
3.1
通讯作者：
Weaver SC
中科院分区：
文献类型：
--
作者：
Coffey LL;Forrester N;Tsetsarkin K;Vasilakis N;Weaver SC
传染病出现或重新出现的许多例子涉及人畜共患病毒对新的扩增宿主或人类本身的适应。这些包括几个简单的突变适应的例子，通常是与天然水库密切相关的宿主。然而，基于理论基础，节肢动物传播的病毒或虫媒病毒可能面临适应新宿主的若干挑战。在这里，我们回顾了最近的研究结果，虫媒病毒的适应性进化及其对疾病的出现的影响。我们专注于人畜共患甲病毒委内瑞拉马脑炎和基孔肯雅病毒，它们经历了适应性进化，介导了最近的疾病爆发，以及黄病毒登革热和西尼罗河病毒，它们通过不太引人注目的适应机制出现。
Many examples of the emergence or re-emergence of infectious diseases involve the adaptation of zoonotic viruses to new amplification hosts or to humans themselves. These include several instances of simple mutational adaptations, often to hosts closely related to the natural reservoirs. However, based on theoretical grounds, arthropod-borne viruses, or arboviruses, may face several challenges for adaptation to new hosts. Here, we review recent findings regarding adaptive evolution of arboviruses and its impact on disease emergence. We focus on the zoonotic alphaviruses Venezuelan equine encephalitis and chikungunya viruses, which have undergone adaptive evolution that mediated recent outbreaks of disease, as well as the flaviviruses dengue and West Nile viruses, which have emerged via less dramatic adaptive mechanisms.
登录
查看更多内容
影响因子：
3.8
作者：
Aguilar, Patricia V.;Adams, A. Paige;Kochel, Tadeusz J.
通讯作者：
Kochel, Tadeusz J.
影响因子：
3.8
作者：
Cardosa J;Ooi MH;Tio PH;Perera D;Holmes EC;Bibi K;Abdul Manap Z
通讯作者：
Abdul Manap Z
DOI：
10.3390/v3091562
发表时间：
2011-09
期刊：
Viruses
影响因子：
--
作者：
Chen R;Vasilakis N
通讯作者：
Vasilakis N
影响因子：
3.8
作者：
Ciota, Alexander T.;Ngo, Kiet A.;Kramer, Laura D.
通讯作者：
Kramer, Laura D.
DOI：
10.1073/pnas.1111650108
发表时间：
2011-09-20
影响因子：
11.1
作者：
Coffey, Lark L.;Beeharry, Yasnee;Vignuzzi, Marco
通讯作者：
Vignuzzi, Marco