A New Sensor Method for Studying the Effect of Gentamicin and Cefotaxime Combination Against Escherichia coli

A New Sensor Method for Studying the Effect of Gentamicin and Cefotaxime Combination Against Escherichia coli
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研究庆大霉素和头孢噻肟组合对大肠杆菌作用的新传感器方法

DOI:
10.1080/00032710903243562
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发表时间:
2009-10
期刊:
影响因子:
2
通讯作者:
He, Fengjiao
He, Fengjiao
中科院分区:
化学4区
文献类型:
--
作者:
Zhou, Juan;He, Fengjiao

文献摘要

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摘要提出了一种基于多通道串联压电石英晶体(MSPQC)的传感器方法,用于研究庆大霉素和头孢噻肟联合使用对大肠杆菌ATCC 25922的抑制作用。得到了不同组合方案下的频率曲线,并进行了比较。当抗生素对细菌生长有抑制作用时,频率检测时间(FDT)会延长。FDT用于评估抗生素组合的效果。利用该方法,对同时给药、不同给药顺序、非同时给药时间间隔等问题进行了详细研究。MSPQC方法可以实时提供过程信息。它简单,快速,易于执行。
Abstract A new sensor method based on a multi-channel series piezoelectric quartz crystal (MSPQC) was proposed for studying the effect of gentamicin and cefotaxime combination against Escherichia coli ATCC 25922. The frequency curves under different combination regimens were obtained and compared with each other. When antibiotic had an inhibitory effect to the growth of bacteria, frequency detection time (FDT) would be prolonged. The FDT was used to assess the effect of an antibiotic combination. By using the proposed method, simultaneous administration, different order, and time interval of nonsimultaneous administration were investigated in detail. The MSPQC method can provide the process information in real time. It is simple, rapid, and easy to perform.
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