Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead.
Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead.
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DOI：
10.1289/ehp.9786
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发表时间：
2007-03
影响因子：
10.4
通讯作者：
Schwartz, Brian S.
中科院分区：
文献类型：
--
作者：
Shih, Regina A.;Hu, Howard;Weisskopf, Marc G.;Schwartz, Brian S.
我们回顾了成年人近期和累积铅剂量与认知功能关系的经验证据。对电子数据库的系统搜索导致了1996年至2006年的21项环境和职业研究，这些研究检查并比较了近期（血液中）和累积（骨骼中）铅剂量与神经行为结果的关系。在考虑排除标准和质量评估后提取数据，然后汇编成汇总表。在环境暴露后遇到的暴露水平，与累积剂量的生物标志物（主要是胫骨中的铅）的关联比与血铅水平的关联更强，更一致。同样，在对过去职业性铅暴露的前工人的研究中，与最近剂量（血液）相比，与累积剂量的关联也更强，更一致。相比之下，对目前暴露于铅的工人的研究通常发现血铅水平的关联更明显;我们推测，近期高剂量的急性效应可能掩盖了累积剂量的慢性效应。有中度证据表明精神症状与铅剂量之间存在关联，但仅在当前职业铅暴露水平较高或环境暴露成人累积剂量较高的情况下。
We review empirical evidence for the relations of recent and cumulative lead dose with cognitive function in adults. A systematic search of electronic databases resulted in 21 environmental and occupational studies from 1996 to 2006 that examined and compared associations of recent (in blood) and cumulative (in bone) lead doses with neurobehavioral outcomes. Data were abstracted after consideration of exclusion criteria and quality assessment, and then compiled into summary tables. At exposure levels encountered after environmental exposure, associations with bio-markers of cumulative dose (mainly lead in tibia) were stronger and more consistent than associations with blood lead levels. Similarly, in studies of former workers with past occupational lead exposure, associations were also stronger and more consistent with cumulative dose than with recent dose (in blood). In contrast, studies of currently exposed workers generally found associations that were more apparent with blood lead levels; we speculate that the acute effects of high, recent dose may mask the chronic effects of cumulative dose. There is moderate evidence for an association between psychiatric symptoms and lead dose but only at high levels of current occupational lead exposure or with cumulative dose in environmentally exposed adults.
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影响因子：
2.7
作者：
Eichenbaum, H
通讯作者：
Eichenbaum, H
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作者：
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