Differences in Cortical Thickness in Schizophrenia Patients With and Without Auditory Verbal Hallucinations.
Differences in Cortical Thickness in Schizophrenia Patients With and Without Auditory Verbal Hallucinations.
复制标题
有和没有幻听的精神分裂症患者皮质厚度的差异
DOI：
10.3389/fnmol.2022.845970
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发表时间：
2022
影响因子：
4.8
通讯作者：
Tang, Jinsong
中科院分区：
文献类型：
--
作者：
Ren, Honghong;Wang, Qianjin;Li, Chunwang;Li, Zongchang;Li, Jinguang;Dai, Lulin;Dong, Min;Zhou, Jun;He, Jingqi;Liao, Yanhui;He, Ying;Chen, Xiaogang;Tang, Jinsong
关键词：
听觉言语幻觉(AVH)是精神分裂症(SCZ)最常见和最严重的症状之一，但AVH背后的神经解剖学机制尚不清楚。本研究旨在探讨持续性脑动静脉高压(PAVH)是否与SCZ患者某些脑区皮质变薄有关。应用3T磁共振成像(MRI)技术，对79例合并pAVH的SCZ患者(pAVH组)、60例不伴pAVH的SCZ患者(非AVH组)和83例健康对照(HC组)的脑血管成像数据进行分析。用阳性与阴性症状量表(PANSS)中的P3幻觉项目和幻听评定量表(AHRS)评定PAVH的严重程度。皮质厚度分析用于比较两组间的感兴趣区(ROI)皮质厚度。并探讨了pAVH的严重程度与皮质厚度的关系。与非aVH组和HC组相比，pAVH组双侧眶前外侧区皮质厚度显著减少(P<；0.0007，经Bonferroni校正后)，而非aVH组和HC组之间无显著差异。左侧眶前叶皮质厚度(P3：r=−0.44，p<；0.001；AHRS：r=−0.45，p<；0.001)和右侧眶前叶皮质厚度(P3：r=−0.36，p=0.002；AHRS：r=−0.33，p=0.004)与pAVH的严重程度(Bonferroni校正后，p<；0.0125)呈负相关。因此，SCZ患者双侧眶前叶皮质厚度异常可能与pAVH有关。
Auditory verbal hallucinations (AVHs) are one of the most common and severe symptoms of schizophrenia (SCZ), but the neuroanatomical mechanisms underlying AVHs remain unclear. This study aimed to investigate whether persistent AVHs (pAVH) are associated with cortical thinning of certain brain regions in patients with SCZ. With the use of the 3T magnetic resonance imaging (MRI) technology, we acquired and analyzed data from 79 SCZ patients with pAVH (pAVH group), 60 SCZ patients without AVHs (non-AVH group), and 83 healthy controls (HC group). The severity of pAVH was assessed by the P3 hallucination items in the Positive and Negative Syndrome Scale (PANSS) and the Auditory Hallucinations Rating Scale (AHRS). Cortical thickness analysis was used to compare the region of interest (ROI) cortical thickness between the groups. The relationship between the severity of pAVH and cortical thickness was also explored. Compared with the non-AVH and HC groups, the pAVH group exhibited significantly reduced cortical thickness in the bilateral lateral orbitofrontal region (p < 0.0007, after Bonferroni correction); no significant difference was found between the non-AVH group and the HC group. The cortical thickness of the left lateral orbitofrontal cortex (P3: r = −0.44, p < 0.001; AHRS: r = −0.45, p < 0.001) and the right lateral orbitofrontal cortex (P3: r = −0.36, p = 0.002; AHRS: r = −0.33, p = 0.004) were negatively correlated with the severity of pAVH (after Bonferroni correction, p < 0.0125). Therefore, abnormal thickness of the bilateral lateral orbitofrontal cortices might be associated with pAVHs in SCZ patients.
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首发精神分裂症患者右侧赫施尔回皮质厚度减少与幻听严重程度相关
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