Reduced cortical thickness in right Heschl's gyrus associated with auditory verbal hallucinations severity in first-episode schizophrenia.
Reduced cortical thickness in right Heschl's gyrus associated with auditory verbal hallucinations severity in first-episode schizophrenia.
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首发精神分裂症患者右侧赫施尔回皮质厚度减少与幻听严重程度相关
DOI：
10.1186/s12888-015-0546-2
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发表时间：
2015-07-07
期刊：
影响因子：
4.4
通讯作者：
Xue Z
中科院分区：
文献类型：
--
作者：
Chen X;Liang S;Pu W;Song Y;Mwansisya TE;Yang Q;Liu H;Liu Z;Shan B;Xue Z
听觉言语幻觉（AVH）是精神分裂症中最有趣的现象之一，然而，AVH背后的大脑异常仍不清楚。本研究旨在探讨首发精神分裂症患者大脑皮层厚度与AVH之间的关系。对49例首发精神分裂症（FES）患者和50例匹配良好的健康对照者（HC）进行了高分辨率MR成像。在FES患者中，18例患有持续性AVH（“幻听”AH组），31例从未经历过AVH（“无幻听”NH组）。AVH的严重程度由听觉幻觉评定量表（AHRS）评定。研究了三组之间的皮质厚度差异及其与AVH严重程度的相关性。与HC和NH患者相比，AH患者的右侧Heschl回皮质厚度较低。皮质厚度的减少程度与AH患者的AVH严重程度相关。Heschl回皮层厚度的减少可能是精神分裂症言语幻听的一个生理因素。本文的在线版本（doi：10.1186/s12888-015-0546-2）包含补充材料，可供授权用户使用。
Auditory verbal hallucinations (AVHs) represent one of the most intriguing phenomena in schizophrenia, however, brain abnormalities underlying AVHs remain unclear. The present study examined the association between cortical thickness and AVHs in first-episode schizophrenia. High-resolution MR images were obtained in 49 first-episode schizophrenia (FES) patients and 50 well-matched healthy controls (HCs). Among the FES patients, 18 suffered persistent AVHs (“auditory hallucination” AH group), and 31 never experienced AVHs (“no hallucination” NH group). The severity of AVHs was rated by the Auditory Hallucinations Rating Scale (AHRS). Cortical thickness differences among the three groups and their association with AVHs severity were examined. Compared to both HCs and NH patients, AH patients showed lower cortical thickness in the right Heschl’s gyrus. The degree of reduction in the cortical thickness was correlated with AVH severity in the AH patients. Abnormalities of cortical thickness in the Heschl’s gyrus may be a physiological factor underlying auditory verbal hallucinations in schizophrenia. The online version of this article (doi:10.1186/s12888-015-0546-2) contains supplementary material, which is available to authorized users.
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影响因子：
2.9
作者：
Kompus K;Falkenberg LE;Bless JJ;Johnsen E;Kroken RA;Kråkvik B;Larøi F;Løberg EM;Vedul-Kjelsås E;Westerhausen R;Hugdahl K
通讯作者：
Hugdahl K
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影响因子：
2
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通讯作者：
Hoffman, Ralph E.
影响因子：
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作者：
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通讯作者：
Tohen, M
影响因子：
10.6
作者：
Levitan, C;Ward, PB;Catts, SV
通讯作者：
Catts, SV