Immunotherapy, targeted therapy, and their cross talks in hepatocellular carcinoma.
Immunotherapy, targeted therapy, and their cross talks in hepatocellular carcinoma.
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DOI：
10.3389/fimmu.2023.1285370
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发表时间：
2023
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
肝细胞癌（HCC）是一种具有挑战性的恶性肿瘤，除了手术和化疗外，治疗选择有限。靶向治疗和免疫治疗的最新进展，包括PD-1和PD-L1单克隆抗体，已显示出希望，但其疗效尚未达到预期。基于基因突变和其他生物标志物的生物标志物检测和个性化医学代表了HCC治疗的未来方向。为了应对这些挑战和机遇，本综述讨论了肝癌靶向治疗和免疫治疗的进展，重点分析了结合这些治疗方式的原理、机遇和挑战。肝脏独特的生理学和许多HCC患者中纤维化的存在对药物递送和功效提出了额外的挑战。在生物标志物开发和联合治疗设计方面的持续努力，特别是在免疫治疗的背景下，有望改善晚期HCC的结局。本文通过对生物标志物和靶向治疗的研究进展进行综述，探讨了该领域的挑战和机遇，并提出了合理的联合治疗设计策略。
Hepatocellular carcinoma (HCC) is a challenging malignancy with limited treatment options beyond surgery and chemotherapy. Recent advancements in targeted therapies and immunotherapy, including PD-1 and PD-L1 monoclonal antibodies, have shown promise, but their efficacy has not met expectations. Biomarker testing and personalized medicine based on genetic mutations and other biomarkers represent the future direction for HCC treatment. To address these challenges and opportunities, this comprehensive review discusses the progress made in targeted therapies and immunotherapies for HCC, focusing on dissecting the rationales, opportunities, and challenges for combining these modalities. The liver’s unique physiology and the presence of fibrosis in many HCC patients pose additional challenges to drug delivery and efficacy. Ongoing efforts in biomarker development and combination therapy design, especially in the context of immunotherapies, hold promise for improving outcomes in advanced HCC. Through exploring the advancements in biomarkers and targeted therapies, this review provides insights into the challenges and opportunities in the field and proposes strategies for rational combination therapy design.
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影响因子：
7.3
作者：
通讯作者：
--
影响因子：
5.2
作者：
Imajyo I;Sugiura T;Kobayashi Y;Shimoda M;Ishii K;Akimoto N;Yoshihama N;Kobayashi I;Mori Y
通讯作者：
Mori Y
影响因子：
4.7
作者：
通讯作者：
--
DOI：
10.1016/j.bbrc.2006.07.124
发表时间：
2006-09-29
影响因子：
3.1
作者：
Boehm, Johann;Sustmann, Claudio;Kohlhase, Juergen
通讯作者：
Kohlhase, Juergen
影响因子：
25.7
作者：
Cheng, Ann-Lii;Qin, Shukui;Finn, Richard S.
通讯作者：
Finn, Richard S.