T-box transcription factor Brachyury expression is correlated with epithelial-mesenchymal transition and lymph node metastasis in oral squamous cell carcinoma.
T-box transcription factor Brachyury expression is correlated with epithelial-mesenchymal transition and lymph node metastasis in oral squamous cell carcinoma.
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DOI：
10.3892/ijo.2012.1673
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发表时间：
2012-12
影响因子：
5.2
通讯作者：
Mori Y
中科院分区：
文献类型：
--
作者：
Imajyo I;Sugiura T;Kobayashi Y;Shimoda M;Ishii K;Akimoto N;Yoshihama N;Kobayashi I;Mori Y
口腔鳞状细胞癌(SCC)患者的预后受淋巴结转移的影响。上皮-间充质转化(EMT)是一种将黏附的上皮细胞转化为可侵袭细胞外基质的单个迁移细胞的过程，对癌症的进展至关重要。最近，T-box转录因子brachyury被报道在人癌细胞系中促进EMT。我们分析了口腔鳞状细胞癌中EMT(通过E-钙粘蛋白和Vimentin染色评估)和短暂性蛋白表达与淋巴结转移的关系。应用免疫组织化学方法检测152例口腔鳞状细胞癌活检标本中E-钙粘蛋白、波形蛋白和短缩蛋白的表达。短臂蛋白的表达与子宫肌层转移呈正相关(p=0.035.0 5)，与淋巴结转移和远处转移显著相关(p<0.0 5)。Logistic回归分析显示，近距离转移和转移是淋巴结转移的预测因素(优势比分别为4.390和5.936)，转移是远处转移的预测因素(优势比11.786)。我们的研究结果为口腔鳞状细胞癌的EMT提供了重要的临床证据，并提示短距离和EMT模式是有用的预后标记物。
The prognosis of patients with oral squamous cell carcinoma (SCC) is influenced by the presence of lymph node metastasis. Epithelial-mesenchymal transition (EMT), a process that involves events that convert adherent epithelial cells into individual migratory cells that can invade the extracellular matrix, is critical for cancer progression. Recently, the T-box transcription factor Brachyury was reported to promote EMT in human carcinoma cell lines. We analyzed the relationship between EMT (assessed by staining for E-cadherin and Vimentin) and the expression of Brachyury in association with lymph node metastasis in oral SCC. Oral SCC biopsy specimens (152 cases) were examined immunohistochemically for the expression of E-cadherin, Vimentin and Brachyury. Expression of Brachyury was correlated with EMT (p=0.035) and was significantly associated with lymph node and distant metastasis (p<0.05). Logistic regression analysis showed that Brachyury and EMT were predictive factors for lymph node metastasis (odds ratio 4.390 and 5.936, respectively) and that EMT was a predictive factor for distant metastases (odds ratio 11.786). Our findings present clinical evidence for an important role of Brachyury in EMT in oral SCC, and suggest that Brachyury and EMT patterns are useful prognostic markers.
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DOI：
10.1186/1756-9966-28-158
发表时间：
2009-12-21
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Sasaki K;Natsugoe S;Ishigami S;Matsumoto M;Okumura H;Setoyama T;Uchikado Y;Kita Y;Tamotsu K;Sakamoto A;Owaki T;Aikou T
通讯作者：
Aikou T
影响因子：
3.8
作者：
Soini Y;Tuhkanen H;Sironen R;Virtanen I;Kataja V;Auvinen P;Mannermaa A;Kosma VM
通讯作者：
Kosma VM
影响因子：
10.5
作者：
KISPERT, A;HERRMANN, BG;REUTER, R
通讯作者：
REUTER, R
影响因子：
4.2
作者：
Otsuki, Sho;Inokuchi, Mikito;Sugihara, Kenichi
通讯作者：
Sugihara, Kenichi
影响因子：
3.6
作者：
Karreth, F;Tuveson, DA
通讯作者：
Tuveson, DA