Memory monitoring performance and PFC activity are associated with 5-HTTLPR genotype in older adults.
Memory monitoring performance and PFC activity are associated with 5-HTTLPR genotype in older adults.
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DOI：
10.1016/j.neuropsychologia.2012.05.030
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发表时间：
2012-07
期刊：
影响因子：
2.6
通讯作者：
Schnyer DM
中科院分区：
文献类型：
--
作者：
Pacheco J;Beevers CG;McGeary JE;Schnyer DM
老年人在认知表现方面表现出广泛的差异，包括情景记忆。这种变异性的一部分可能由遗传因素解释。最近的文献表明，神经递质5-羟色胺在记忆过程中起着重要作用，因为大脑5-羟色胺的增强导致记忆力的改善。在这里，我们已经开始探索基因对与源记忆监测相关的表现和潜在大脑活动的贡献。在功能磁共振成像扫描过程中使用源识别记忆任务，本研究提供的证据表明，携带SLC 6A 4基因中5-羟色胺转运蛋白连锁多态性区域（5-HTTLPR）的短等位基因（S-car）的老年人相对于长等位基因（LL）纯合子的老年人在源记忆监测方面表现出特定的缺陷。这些缺陷伴随着前额叶皮层区域的神经活动减少，这些区域已被证明支持准确的记忆监测。此外，虽然老年人LL组的行为表现与年轻人没有区别，但他们的大脑激活揭示了可能支持其更高表现水平的补偿激活的证据。这些结果提供了初步证据，证明长等位基因纯合子谱对老年人的认知有益，特别是记忆功能。
Older adults show extensive variability in cognitive performance, including episodic memory. A portion of this variability could potentially be explained by genetic factors. Recent literature shows that the neurotransmitter serotonin plays an important role in memory processes, as enhancements of brain serotonin have led to memory improvement. Here, we have begun to explore genetic contributions to the performance and underlying brain activity associated with source memory monitoring. Using a source recognition memory task during fMRI scanning, this study offers evidence that older adults who carry a short allele (S-car) of the serotonin transporter linked polymorphic region (5-HTTLPR) in the SLC6A4 gene show specific deficits in source memory monitoring relative to older adults who are homozygous for the long allele (LL). These deficits are accompanied by less neural activity in regions of prefrontal cortex that have been shown to support accurate memory monitoring. Moreover, while the older adult LL group’s behavioral performance does not differ from younger adults, their brain activation reveals evidence of compensatory activation that likely supports their higher performance level. These results provide preliminary evidence that the long-allele homozygous profile is cognitively beneficial to older adults, particularly for memory functioning.
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影响因子：
3.7
作者：
Chua, Elizabeth F.;Schacter, Daniel L.;Sperling, Reisa A.
通讯作者：
Sperling, Reisa A.
影响因子：
16.2
作者：
Dobbins, IG;Foley, H;Wagner, AD
通讯作者：
Wagner, AD
影响因子：
5.7
作者：
Chua, EF;Schacter, DL;Sperling, RA
通讯作者：
Sperling, RA
影响因子：
2.5
作者：
Beevers, C. G.;Pacheco, J.;Schnyer, D.
通讯作者：
Schnyer, D.
DOI：
10.1093/geronb/61.6.p340
发表时间：
2006-11-01
影响因子：
6.2
作者：
Eakin, Deborah K.;Hertzog, Christopher
通讯作者：
Hertzog, Christopher