Stem Cell-Derived Exosomes as Therapeutic Approach for Neurodegenerative Disorders: From Biology to Biotechnology.
Stem Cell-Derived Exosomes as Therapeutic Approach for Neurodegenerative Disorders: From Biology to Biotechnology.
复制标题
干细胞衍生的外泌体作为神经退行性疾病的治疗方法：从生物学到生物技术。
DOI：
10.3390/cells9122663
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发表时间：
2020-12-11
期刊：
影响因子：
6
通讯作者：
Kerkis I
中科院分区：
文献类型：
--
作者：
Araldi RP;D'Amelio F;Vigerelli H;de Melo TC;Kerkis I
人口老龄化导致全球神经退行性疾病发病率迅速上升。尽管医学进步，但对这些疾病没有有效的治疗方法。因此，迫切需要针对这些疾病的新疗法。从这个意义上说，细胞疗法已被公认为治疗不治之症，如神经退行性疾病的最佳候选人。然而，这些细胞的治疗用途可能受到几个因素的限制。因此，已经重新发现，细胞外囊泡，包括外来体，可以在这些疾病的治疗中替代地探索，克服基于细胞的治疗的限制。从这个意义上说，这篇综述旨在重新审视从生物学（包括生物起源和外泌体内容）到生物技术的所有领域，提出为科学和/或临床目的分离、表征和研究这些囊泡内容所需的最少信息。
The aging population has contributed to the rapid rise in the global incidence of neurodegenerative diseases. Despite the medical advances, there are no effective treatments for these disorders. Therefore, there is an urgent need for new treatments for these diseases. In this sense, cell therapy has been recognized as the best candidate for treating incurable diseases, such as neurodegenerative disorders. However, the therapeutic use of these cells can be limited by several factors. Thus, there has been a rediscovery that extracellular vesicles, including exosomes, can be alternatively explored in the treatment of these diseases, overcoming the limits of cell-based therapy. In this sense, this review aims to revisit all areas from biology, including biogenesis and the content of exosomes, to biotechnology, proposing the minimal information required to isolate, characterize, and study the content of these vesicles for scientific and/or clinical purposes.
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