Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts.
Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts.
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DOI：
10.1080/21505594.2022.2150445
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发表时间：
2023-12
期刊：
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
非洲锥虫是媒介传播的原生动物，在撒哈拉以南非洲造成严重的人类和动物疾病，在亚洲和南美洲造成动物疾病。在人类中，感染是由布氏锥虫的变体引起的，并且其特征在于由寄生虫离开脉管系统并进入大脑引起的进展为神经系统疾病的不同速率。动物疾病是由多种锥虫引起的，主要是锥虫。congolense，T.间日疟和T.布鲁塞。这些锥虫也感染多个物种的哺乳动物宿主，锥虫和宿主多样性的这种复杂性反映在动物锥虫病的疾病严重程度谱中，从与死亡相关的超急性感染到长期慢性感染，这也是为什么设计动物锥虫病干预措施如此具有挑战性的主要原因。在这篇综述中，我们将提供一个概述目前的理解锥虫感染的进展和严重程度的决定因素，包括实验室模型的疾病，以及人类和牲畜的疾病。我们还将强调知识和能力方面的差距，这些差距代表了进一步了解锥虫如何引起疾病的机会，以及促进开发迫切需要减少这些重要病原体引起的疾病负担的新型干预措施。
African trypanosomes are vector-borne protozoa, which cause significant human and animal disease across sub-Saharan Africa, and animal disease across Asia and South America. In humans, infection is caused by variants of Trypanosoma brucei, and is characterized by varying rate of progression to neurological disease, caused by parasites exiting the vasculature and entering the brain. Animal disease is caused by multiple species of trypanosome, primarily T. congolense, T. vivax, and T. brucei. These trypanosomes also infect multiple species of mammalian host, and this complexity of trypanosome and host diversity is reflected in the spectrum of severity of disease in animal trypanosomiasis, ranging from hyperacute infections associated with mortality to long-term chronic infections, and is also a main reason why designing interventions for animal trypanosomiasis is so challenging. In this review, we will provide an overview of the current understanding of trypanosome determinants of infection progression and severity, covering laboratory models of disease, as well as human and livestock disease. We will also highlight gaps in knowledge and capabilities, which represent opportunities to both further our fundamental understanding of how trypanosomes cause disease, as well as facilitating the development of the novel interventions that are so badly needed to reduce the burden of disease caused by these important pathogens.
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影响因子：
3.8
作者：
Levy DJ;Goundry A;Laires RSS;Costa TFR;Novo CM;Grab DJ;Mottram JC;Lima APCA
通讯作者：
Lima APCA
影响因子：
3.8
作者：
Auty HK;Picozzi K;Malele I;Torr SJ;Cleaveland S;Welburn S
通讯作者：
Welburn S
影响因子：
2.4
作者：
BARRY, JD
通讯作者：
BARRY, JD
DOI：
10.1155/2016/4503214
发表时间：
2016-01-01
期刊：
Pathology research international
影响因子：
--
作者：
Boada-Sucre, Alpidio A;Rossi Spadafora, Marcello Salvatore;Reyna-Bello, Armando
通讯作者：
Reyna-Bello, Armando
影响因子：
2.6
作者：
Bengaly, Z;Sidibe, I;Desquesnes, M
通讯作者：
Desquesnes, M