Impact of statins on progression of atherosclerosis: rationale and design of SATURN (Study of Coronary Atheroma by InTravascular Ultrasound: Effect of Rosuvastatin versus AtorvastatiN)
Impact of statins on progression of atherosclerosis: rationale and design of SATURN (Study of Coronary Atheroma by InTravascular Ultrasound: Effect of Rosuvastatin versus AtorvastatiN)
复制标题
他汀类药物对动脉粥样硬化进展的影响：SATURN 的基本原理和设计（血管内超声研究冠状动脉粥样硬化：瑞舒伐他汀与阿托伐他汀的效果）
DOI：
--
复制
发表时间：
2011
影响因子：
2.3
通讯作者：
P. Libby
中科院分区：
文献类型：
--
作者：
S. Nicholls;Marilyn Borgman;S. Nissen;J. Raichlen;C. Ballantyne;P. Barter;J. Chapman;R. Erbel;P. Libby
摘要背景：以往的影像研究表明，大剂量他汀类药物对冠状动脉粥样硬化进展的有益影响与其降低低密度脂蛋白胆固醇(LDL-C)和C反应蛋白(CRP)水平以及升高高密度脂蛋白胆固醇(HDL-C)的能力有关。血管内超声对冠状动脉动脉粥样硬化的研究：罗舒伐他汀与阿托伐他汀的作用(saturn，NCT00620542)旨在比较大剂量阿托伐他汀和瑞舒伐他汀对疾病进展的影响。方法：1385例冠状动脉造影确诊的冠心病患者随机分为瑞舒伐他汀40 mg组和阿托伐他汀80 mg组，疗程24个月。主要的疗效参数将是动脉粥样硬化体积(PAV)的名义变化，通过分析在基线和24个月随访时获得的匹配冠状动脉节段的血管内超声(IVUS)图像来确定。他汀类药物治疗对血脂和炎症标志物的影响，以及临床心血管事件的发生率也将被评估。这项研究没有统计能力来直接比较治疗组的临床事件。结论：系列静脉内超声已成为评估治疗对动脉结构影响的一种灵敏的成像手段。在这项研究中，IVUS将用于确定大剂量他汀类药物对斑块进展是否有不同的影响。
Abstract Background: Previous imaging studies have demonstrated that the beneficial impact of high-dose statins on the progression of coronary atherosclerosis associates with their ability to lower levels of low-density lipoprotein cholesterol (LDL-C) and C-reactive protein (CRP) and to raise high-density lipoprotein cholesterol (HDL-C). The Study of Coronary Atheroma by InTravascular Ultrasound: Effect of Rosuvastatin versus AtorvastatiN (SATURN, NCT00620542) aims to compare the effects of high-dose atorvastatin and rosuvastatin on disease progression. Methods: A total of 1385 subjects with established coronary artery disease (CAD) on angiography were randomized to receive rosuvastatin 40 mg or atorvastatin 80 mg for 24 months. The primary efficacy parameter will be the nominal change in percent atheroma volume (PAV), determined by analysis of intravascular ultrasound (IVUS) images of matched coronary artery segments acquired at baseline and at 24-month follow-up. The effect of statin therapy on plasma lipids and inflammatory markers, and the incidence of clinical cardiovascular events will also be assessed. The study does not have the statistical power to directly compare the treatment groups with regard to clinical events. Conclusion: Serial IVUS has emerged as a sensitive imaging modality to assess the impact of treatments on arterial structure. In this study, IVUS will be used to determine whether high-dose statins have different effects on plaque progression.
登录
查看更多内容
影响因子：
24
作者：
Libby, P
通讯作者：
Libby, P
影响因子：
120.7
作者：
Greenland, P;LaBree, L;Detrano, RC
通讯作者：
Detrano, RC
影响因子：
5
作者：
Chambless, LE;Heiss, G;Clegg, LX
通讯作者：
Clegg, LX
猪模型中实验性冠状动脉病变的无创体内磁共振成像。
影响因子：
37.8
作者：
Worthley,SG;Helft,G;Fuster,V;Fayad,ZA;Rodriguez,OJ;Zaman,AG;Fallon,JT;Badimon,JJ
通讯作者：
Badimon,JJ
影响因子：
158.5
作者：
Brown, BG;Zhao, XQ;Dodek, A
通讯作者：
Dodek, A