Noninvasive in vivo magnetic resonance imaging of experimental coronary artery lesions in a porcine model.
Noninvasive in vivo magnetic resonance imaging of experimental coronary artery lesions in a porcine model.
复制标题
猪模型中实验性冠状动脉病变的无创体内磁共振成像。
DOI：
10.1161/01.cir.101.25.2956
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发表时间：
2000
期刊：
影响因子：
37.8
通讯作者：
Badimon,JJ
中科院分区：
文献类型：
--
作者：
Worthley,SG;Helft,G;Fuster,V;Fayad,ZA;Rodriguez,OJ;Zaman,AG;Fallon,JT;Badimon,JJ
背景：准确、可重复性和无创地表征和量化冠状动脉粥样硬化病变的能力可能允许对未来急性冠状动脉综合征的风险进行分层，并有助于指导治疗管理。MRI已被证明可以准确地表征和量化动脉粥样硬化；然而，由于心脏和呼吸运动的伪影、非线性过程和冠状动脉相对较小的尺寸，这些技术还不能转化为体内冠状动脉系统。方法与结果：采用球囊血管成形术诱导6头约克郡白化猪冠状动脉病变，4周后行冠状动脉MRI检查。在1.5 t MR系统中，通过双反转-恢复快速自旋回波序列获得冠状动脉壁和病变的高分辨率活体图像。冠状动脉MR图像测量的血管壁厚度和面积与匹配的组织病理学切片（n=43）吻合良好。平均壁厚差（MRI减去组织病理学±SD）为0.26±0.18 mm，血管壁面积差为5.65±3.51 mm2。MRI也能显示病灶内血肿（敏感性82%，特异性84%）。结论：使用临床磁共振系统，我们能够在实验猪模型中对体内冠状动脉病变进行成像。需要进一步的研究来评估MRI在体内表征冠状动脉粥样硬化病变的能力。
Background—The ability to characterize and quantify coronary artery atherosclerotic lesions accurately, reproducibly, and noninvasively may allow the stratification of risk for future acute coronary syndromes and help direct therapeutic management. MRI has been shown to accurately characterize and quantify atherosclerosis; however, because of the combination of cardiac and respiratory motion artifacts, nonlinear course, and relatively small size of the coronary arteries, these techniques have not been able to be translated to the coronary system in vivo.Methods and Results—Coronary lesions were induced in Yorkshire albino swine (n=6) with balloon angioplasty, and 4 weeks later MRI of the coronary artery lesions was performed. High-resolution in vivo images of the coronary artery wall and lesions were obtained with a double-inversion-recovery fast-spin-echo sequence in a 1.5-T MR system. There was good agreement between measurements of vessel wall thickness and area from MR images of the coronary arteries and the matched histopathology sections (n=43). The mean difference (MRI minus histopathology ± SD) for mean wall thickness was 0.26±0.18 mm, and for vessel wall area, 5.65±3.51 mm2. MRI was also able to visualize intralesion hematoma (sensitivity 82%, specificity 84%).Conclusions—Using a clinical MR system, we were able to image coronary artery lesions in vivo in an experimental porcine model. Further studies are needed to assess the ability of MRI to characterize coronary atherosclerotic lesions in vivo.
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影响因子：
39.3
作者：
M. Grønholdt;S. Dalager-Pedersen;E. Falk
通讯作者：
M. Grønholdt;S. Dalager-Pedersen;E. Falk
影响因子：
5.3
作者：
Worthley, SG;Helft, G;Badimon, JJ
通讯作者：
Badimon, JJ
影响因子：
37.8
作者：
Fayad, ZA;Fallon, JT;Fuster, V
通讯作者：
Fuster, V
影响因子：
82.9
作者：
SKINNER, MP;YUAN, C;ROSS, R
通讯作者：
ROSS, R
不稳定的动脉粥样硬化斑块：临床意义和治疗干预
影响因子：
6.7
作者：
V. Fuster;J. Fallon;J. Badimón;Y. Nemerson
通讯作者：
Y. Nemerson