Trait impulsivity in Juvenile Myoclonic Epilepsy.
Trait impulsivity in Juvenile Myoclonic Epilepsy.
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DOI：
10.1002/acn3.51255
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发表时间：
2021-01
影响因子：
5.3
通讯作者：
BIOJUME Consortium
中科院分区：
文献类型：
--
作者：
Shakeshaft A;Panjwani N;McDowall R;Crudgington H;Peña Ceballos J;Andrade DM;Beier CP;Fong CY;Gesche J;Greenberg DA;Hamandi K;Koht J;Lim KS;Orsini A;Rees MI;Rubboli G;Selmer KK;Smith AB;Striano P;Syvertsen M;Talvik I;Thomas RH;Zarubova J;Richardson MP;Strug LJ;Pal DK;BIOJUME Consortium
冲动是一种多维度的结构，可以诱发精神病理。Meta分析表明反应冲动与青少年肌阵挛性癫痫（JME）之间存在关联，JME是一种常见的遗传性全身性癫痫。在这里，我们检验了以下假设：与对照组相比，JME中的冲动性特质(i)升高；（ii）有特定的癫痫发作特征；（iii）与抗癫痫药物（aed）的精神不良反应有关。322名JME患者和126名年龄和性别匹配的对照组完成了Barratt冲动量表（BIS - brief）以及癫痫发作史和AED使用信息。我们比较了各组BIS - brief评分，并评估了JME BIS - brief评分与癫痫发作特征和AED不良反应的关系。JME患者BIS - brief平均评分为18.1±4.4，对照组为16.2±4.1 （P = 0.0007）。冲动性升高与男性（P = 0.027）、频繁失神发作（P = 0.0004）和肌阵挛缺乏早晨优势（P = 0.008）相关。高冲动性显著增加了左乙拉西坦精神不良事件的发生率（P = 0.036），但没有其他精神或躯体不良反应。性格冲动性在JME中升高，与人格和神经性障碍的得分相当。癫痫发作频率增加和缺乏昼夜节律癫痫发作模式会降低BIS评分，这表明在JME中，皮质纹状体和丘脑皮质网络的破坏是癫痫发作和冲动之间的共同机制。这些发现证明冲动性是干预的一个明确目标，也是JME和其他类型癫痫的AED治疗的一个分层因素。冲动性在治疗依从性和社会心理结果中的作用需要进一步调查。
Impulsivity is a multidimensional construct that can predispose to psychopathology. Meta‐analysis demonstrates an association between response impulsivity and Juvenile Myoclonic Epilepsy (JME), a common genetic generalized epilepsy. Here, we test the hypotheses that trait impulsivity is (i) elevated in JME compared to controls; (ii) moderated by specific seizure characteristics; and (iii) associated with psychiatric adverse effects of antiepileptic drugs (AEDs). 322 participants with JME and 126 age and gender‐matched controls completed the Barratt’s Impulsiveness Scale (BIS‐brief) alongside information on seizure history and AED use. We compared group BIS‐brief scores and assessed associations of JME BIS‐brief scores with seizure characteristics and AED adverse effects. The mean BIS‐brief score in JME was 18.1 ± 4.4 compared with 16.2 ± 4.1 in controls (P = 0.0007). Elevated impulsivity was associated with male gender (P = 0.027), frequent absence seizures (P = 0.0004) and lack of morning predominance of myoclonus (P = 0.008). High impulsivity significantly increased the odds of a psychiatric adverse event on levetiracetam (P = 0.036), but not any other psychiatric or somatic adverse effects. Trait impulsivity is elevated in JME and comparable to scores in personality and neurotic disorders. Increased seizure frequency and absence of circadian seizure pattern moderate BIS score, suggesting disruption of both cortico‐striatal and thalamocortical networks as a shared mechanism between seizures and impulsivity in JME. These findings warrant consideration of impulsivity as a distinct target of intervention, and as a stratifying factor for AED treatment in JME, and perhaps other types of epilepsy. The role of impulsivity in treatment adherence and psychosocial outcome requires further investigation.
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影响因子：
9.9
作者：
Badawy, R. A. B.;Macdonell, R. A. L.;Berkovic, S. F.
通讯作者：
Berkovic, S. F.
影响因子：
3.6
作者：
Mathias CW;Stanford MS;Liang Y;Goros M;Charles NE;Sheftall AH;Mullen J;Hill-Kapturczak N;Acheson A;Olvera RL;Dougherty DM
通讯作者：
Dougherty DM
影响因子：
5.6
作者：
Guilfoyle, Shanna M.;Follansbee-Junger, Katherine;Modi, Avani C.
通讯作者：
Modi, Avani C.
影响因子：
6.9
作者：
Jepsen, J. R. M.;Rydkjaer, J.;Oranje, B.
通讯作者：
Oranje, B.
影响因子：
11.3
作者：
McGowan, Niall M.;Coogan, Andrew N.
通讯作者：
Coogan, Andrew N.