Sex, age, and hunger regulate behavioral prioritization through dynamic modulation of chemoreceptor expression.
Sex, age, and hunger regulate behavioral prioritization through dynamic modulation of chemoreceptor expression.
复制标题
DOI：
10.1016/j.cub.2014.09.032
复制
发表时间：
2014-11-03
期刊：
影响因子：
9.2
通讯作者：
Portman, Douglas S.
中科院分区：
文献类型：
--
作者：
Ryan, Deborah A.;Miller, Renee M.;Lee, KyungHwa;Neal, Scott J.;Fagan, Kelli A.;Sengupta, Piali;Portman, Douglas S.
自适应行为优先级需要固定神经回路的灵活输出。在秀丽隐杆线虫中，进食与寻找配偶的优先顺序取决于生物性别（雄性会放弃食物来寻找配偶，而雌雄同体则不会）以及发育阶段和进食状态。此前，我们发现雄性比雌雄同体对与食物相关的气味剂二乙酰的吸引力较小，这表明感觉调节可能有助于行为优先顺序。我们发现体细胞性行为通过调节 AWA 神经元中的关键化学感受器 odr-10 来自主地重新配置嗅觉回路。此外，我们发现 odr-10 在食品检测中具有重要作用，其调节有助于行为优先顺序的性别差异。 odr-10 的过度表达会增加男性对食物的吸引力并减少对非食物的探索；相反，odr-10 的损失会损害男女的食物出租车。在幼虫中，两性都优先考虑进食而不是探索。相应地，两性具有相同的odr-10表达和食物吸引力。食物匮乏会暂时有利于成年雄性的进食而不是探索，它通过激活 odr-10 的表达来增加雄性的食物吸引力。此外，odr-10在喂养良好的成年雄性中的弱表达具有重要的适应价值，使雄性能够在不均匀的食物环境中有效地找到配偶。我们发现，单个化学感受器的调节表达在进食和探索优先顺序中自然发生的变化中发挥着关键作用。三种独立的调节输入（躯体性别、年龄和喂养状态）对化学感受器表达的融合凸显了感觉功能作为神经回路可塑性的关键来源。
Adaptive behavioral prioritization requires flexible outputs from fixed neural circuits. In C. elegans, the prioritization of feeding vs. mate-searching depends on biological sex (males will abandon food to search for mates, while hermaphrodites will not) as well as developmental stage and feeding status. Previously, we found that males are less attracted than hermaphrodites to the food-associated odorant diacetyl, suggesting that sensory modulation may contribute to behavioral prioritization. We find that somatic sex acts cell-autonomously to reconfigure the olfactory circuit by regulating a key chemoreceptor, odr-10, in the AWA neurons. Moreover, we find that odr-10 has a significant role in food detection, the regulation of which contributes to sex differences in behavioral prioritization. Overexpression of odr-10 increases male food attraction and decreases off-food exploration; conversely, odr-10 loss impairs food taxis in both sexes. In larvae, both sexes prioritize feeding over exploration; correspondingly, the sexes have equal odr-10 expression and food attraction. Food deprivation, which transiently favors feeding over exploration in adult males, increases male food attraction by activating odr-10 expression. Furthermore, the weak expression of odr-10 in well-fed adult males has important adaptive value, allowing males to efficiently locate mates in a patchy food environment. We find that modulated expression of a single chemoreceptor plays a key role in naturally occurring variation in the prioritization of feeding and exploration. The convergence of three independent regulatory inputs—somatic sex, age, and feeding status—on chemoreceptor expression highlights sensory function as a key source of plasticity in neural circuits.
登录
查看更多内容
影响因子：
5.3
作者：
Lipton, J;Kleemann, G;Emmons, SW
通讯作者：
Emmons, SW
DOI：
10.1073/pnas.1312087110
发表时间：
2013-10-01
影响因子：
11.1
作者：
Berkseth, Matt;Ikegami, Kohta;Zarkower, David
通讯作者：
Zarkower, David
影响因子：
64.5
作者：
BARGMANN, CI;HARTWIEG, E;HORVITZ, HR
通讯作者：
HORVITZ, HR
影响因子：
48
作者：
Calixto, Andrea;Chelur, Dattananda;Topalidou, Irini;Chen, Xiaoyin;Chalfie, Martin
通讯作者：
Chalfie, Martin
影响因子：
25
作者：
Barrios, Arantza;Ghosh, Rajarshi;Fang, Chunhui;Emmons, Scott W.;Barr, Maureen M.
通讯作者：
Barr, Maureen M.