Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation.
Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation.
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DOI：
10.1016/j.bbagrm.2010.11.001
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发表时间：
2011-01
影响因子：
4.7
通讯作者：
Adelman, Karen
中科院分区：
文献类型：
--
作者：
Nechaev, Sergei;Adelman, Karen
基因表达的适当调节对于所有细胞和生物体的分化、发育和存活至关重要。最近的工作表明，许多基因的转录，包括关键的发育和刺激反应基因，调节后的起始步骤，通过暂停RNA聚合酶II在延长通过启动子近端区域。因此，人们对更好地理解转录起始后的事件以及调节早期延伸效率以影响这些高度调控基因表达的方式非常感兴趣。在这里，我们描述了我们目前的理解，从一个不稳定的最初转录复杂的过渡到一个高度稳定和进行性延伸复杂的步骤。我们还讨论了影响早期转录延长的因素之间的相互作用和潜在的生理后果的基因，通过转录暂停调节。
Proper regulation of gene expression is essential for the differentiation, development and survival of all cells and organisms. Recent work demonstrates that transcription of many genes, including key developmental and stimulus-responsive genes, is regulated after the initiation step, by pausing of RNA polymerase II during elongation through the promoter-proximal region. Thus, there is great interest in better understanding the events that follow transcription initiation and the ways in which the efficiency of early elongation can be modulated to impact expression of these highly regulated genes. Here we describe our current understanding of the steps involved in the transition from an unstable initially transcribing complex into a highly stable and processive elongation complex. We also discuss the interplay between factors that affect early transcript elongation and the potential physiological consequences for genes that are regulated through transcriptional pausing.
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影响因子：
64.5
作者：
Bai X;Kim J;Yang Z;Jurynec MJ;Akie TE;Lee J;LeBlanc J;Sessa A;Jiang H;DiBiase A;Zhou Y;Grunwald DJ;Lin S;Cantor AB;Orkin SH;Zon LI
通讯作者：
Zon LI
DOI：
10.1016/j.cub.2009.02.055
发表时间：
2009-04-28
期刊：
Current biology : CB
影响因子：
--
作者：
Chopra VS;Hong JW;Levine M
通讯作者：
Levine M
影响因子：
10.5
作者：
Bartkowiak, Bartlomiej;Liu, Pengda;Greenleaf, Arno L.
通讯作者：
Greenleaf, Arno L.
影响因子：
64.5
作者：
Chen, HT;Hahn, S
通讯作者：
Hahn, S
DOI：
10.1073/pnas.0910177106
发表时间：
2009-10-27
影响因子：
11.1
作者：
Adelman, Karen;Kennedy, Megan A.;Rogatsky, Inez
通讯作者：
Rogatsky, Inez