Identification of lipid droplets in gut bacteria.
Identification of lipid droplets in gut bacteria.
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肠道细菌中脂滴的鉴定
DOI：
10.1093/procel/pwac015
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发表时间：
2023-03-16
期刊：
影响因子：
21.1
通讯作者：
Liu, Pingsheng
中科院分区：
文献类型：
--
作者：
Zhang, Kai;Zhou, Chang;Li, Zemin;Li, Xuehan;Zhou, Ziyun;Cheng, Linjia;Mirza, Ahmed Hammad;Shi, Yumeng;Chen, Bingbing;Zhang, Mengwei;Cui, Liujuan;Zhang, Congyan;Wei, Taotao;Zhang, Xuelin;Zhang, Shuyan;Liu, Pingsheng
肠道微生物区系领域正在迅速发展，因此，最后一个人类器官、一个单独的器官、一个被遗忘的器官和一个新的器官等称谓已经被应用到肠道微生物区系中，以强调它在我们身体中的重要功能(Chang和Kao，2019)。肠道微生物区系已被证明在调节人类脂类代谢中发挥核心作用，并在异常时通过组成和微生物代谢物与脂类代谢紊乱相关。例如，肠道微生物区系组成的改变与宿主体内的血脂异常和异位脂肪沉积有关。此外，移植患有肥胖症、2型糖尿病或脂肪变性的供者的粪便微生物群，将部分导致小鼠受体的代谢表型相似(Schoeler和Caesar，2019年)。肠道微生物区系产生的代谢物，如为肠道提供能量并促进肝脏脂肪形成的短链脂肪酸，可能介导对宿主脂肪代谢的影响(Schoeler和Caesar，2019)。已建立了几种复杂的方法来研究肠道微生物区系，包括高通量16S rRNA测序、元基因组学、代谢组学和大规模细菌克隆。肠道中物种的巨大数量和由此产生的复杂性阻碍了阐明微生物区系功能的努力(Lozupone等人，2012年)。相比之下，人类的其他器官和组织是由研究得很好的细胞类型组成的，这些细胞类型含有已知的细胞器，并对它们的分子调控和通讯有了深入的了解。然而，这些基础还没有为肠道微生物区系奠定。因此，需要新的技术和方法来剖析这一重要的生态系统，并阐明它们的细胞通讯、细胞细胞器和分子调控。脂滴(LD)是一种球形的细胞器，由中性脂核组成，外面覆盖着一层单层磷脂膜，上面装饰着驻留/动态蛋白质(Olzmann和Carvalho，2019)。异常的LD动力学和
The field of gut microbiota is progressing rapidly and thus, appellations like the last human organ, a separate organ, a forgotten organ, and a new organ have been applied to gut microbiota to emphasize its vital functions in our body (Chang and Kao, 2019). Gut microbiota has been shown to play a central role in the regulation of human lipid metabolism and be associated with lipid metabolism disorders when aberrant, through composition and microbial metabolites. For instance, alterations in intestinal microbiota composition are associated with dyslipidemia and ectopic fat deposition in host. Moreover, transplantation of the fecal microbiota from donors with obesity, type 2 diabetes, or steatosis would partially result in similar metabolic phenotype in mouse recipients (Schoeler and Caesar, 2019). The metabolites produced by gut microbiota, such as short-chain fatty acids which provide energy for intestine and contribute to lipogenesis in liver, may mediate the influence on host lipid metabolism (Schoeler and Caesar, 2019).Several sophisticated approaches have been established to study gut microbiota, including high-throughput 16S rRNA sequencing, metagenomics, metabolomics, and massive bacterial cloning. The immense number of species in the gut and the resulting complexity have stymied efforts to elucidate the functions of the microbiota (Lozupone et al., 2012). In comparison, other human organs and tissues are composed of well-studied cell types containing known organelles with a developed understanding of their molecular regulation and communication. However, these foundations have not yet been built for gut microbiota. Therefore, new techniques and approaches are required to dissect this important ecosystem and elucidate their cellular communication, cellular organelles, and molecular regulation. The lipid droplet (LD) is a cellular organelle with a globular shape and consists of a neutral lipid core covered by a monolayer phospholipid membrane decorated with resident/dynamic proteins (Olzmann and Carvalho, 2019). Abnormal LD dynamics and
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影响因子：
6.5
作者：
Ding, Yunfeng;Yang, Li;Liu, Pingsheng
通讯作者：
Liu, Pingsheng
影响因子：
7.4
作者：
Singh RK;Chang HW;Yan D;Lee KM;Ucmak D;Wong K;Abrouk M;Farahnik B;Nakamura M;Zhu TH;Bhutani T;Liao W
通讯作者：
Liao W
影响因子：
29.4
作者：
Lepage, Patricia;Haesler, Robert;Schreiber, Stefan
通讯作者：
Schreiber, Stefan
DOI：
10.1007/s10096-012-1787-3
发表时间：
2013-05-01
影响因子：
4.5
作者：
Dubourg, G.;Lagier, J. C.;Raoult, D.
通讯作者：
Raoult, D.
DOI：
10.1016/j.bbadis.2017.07.019
发表时间：
2018-05-01
影响因子：
6.2
作者：
Xu, Shimeng;Zhang, Xuelin;Liu, Pingsheng
通讯作者：
Liu, Pingsheng