Mitochondria as a Cellular Hub in Infection and Inflammation.
Mitochondria as a Cellular Hub in Infection and Inflammation.
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DOI：
10.3390/ijms222111338
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发表时间：
2021-10-20
影响因子：
5.6
通讯作者：
Nunes JPS
中科院分区：
文献类型：
--
作者：
Andrieux P;Chevillard C;Cunha-Neto E;Nunes JPS
线粒体是细胞的能量中心。它们作为动态网络存在于细胞质中，根据细胞的需要调整能量生产。它们也是促炎症反应的中心，并在对抗病原性感染的反应中发挥重要作用。线粒体是产生活性氧（ROS;或自由基）的主要场所，活性氧对于对抗感染是必不可少的。然而，过度和不受控制的生产可能对细胞有害，导致线粒体和组织损伤。病原体通过影响氧化磷酸化机制（OXPHOS）、线粒体网络和破坏细胞核与线粒体之间的通讯来利用线粒体在感染期间的作用。线粒体在这些生物过程中的作用使这些细胞器成为开发治疗策略的良好靶点。在这篇综述中，我们总结了线粒体的内共生起源及其参与病原体反应，以及对抗感染性疾病和慢性炎症性疾病的潜在有前途的线粒体靶点。
Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as dynamic networks where they adapt energy production based on the cell’s needs. They are also at the center of the proinflammatory response and have essential roles in the response against pathogenic infections. Mitochondria are a major site for production of Reactive Oxygen Species (ROS; or free radicals), which are essential to fight infection. However, excessive and uncontrolled production can become deleterious to the cell, leading to mitochondrial and tissue damage. Pathogens exploit the role of mitochondria during infection by affecting the oxidative phosphorylation mechanism (OXPHOS), mitochondrial network and disrupting the communication between the nucleus and the mitochondria. The role of mitochondria in these biological processes makes these organelle good targets for the development of therapeutic strategies. In this review, we presented a summary of the endosymbiotic origin of mitochondria and their involvement in the pathogen response, as well as the potential promising mitochondrial targets for the fight against infectious diseases and chronic inflammatory diseases.
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影响因子：
3.3
作者：
Alkhaja AK;Jans DC;Nikolov M;Vukotic M;Lytovchenko O;Ludewig F;Schliebs W;Riedel D;Urlaub H;Jakobs S;Deckers M
通讯作者：
Deckers M
影响因子：
3.1
作者：
Boncompain, Gaelle;Schneider, Benoit;Subtil, Agathe
通讯作者：
Subtil, Agathe
影响因子：
4.8
作者：
Bianchi, C;Genova, ML;Lenaz, G
通讯作者：
Lenaz, G
影响因子：
10.7
作者：
Berg, OG;Kurland, CG
通讯作者：
Kurland, CG
DOI：
10.1073/pnas.93.2.906
发表时间：
1996-01-23
影响因子：
11.1
作者：
Andersson, DI;Hughes, D
通讯作者：
Hughes, D