On the potential roles of phosphorus in the early evolution of energy metabolism.
On the potential roles of phosphorus in the early evolution of energy metabolism.
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DOI：
10.3389/fmicb.2023.1239189
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发表时间：
2023
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
现存生命的能量代谢以磷酸盐和能量密集的三磷酸腺苷（ATP）的磷酸酐键为中心，这是一个非常保守的古老生物能量系统。然而，ATP的合成依赖于许多复杂的酶，并且对ATP本身具有自催化要求。这意味着存在进化上更简单的生物能量途径和潜在的原始ATP替代品。磷酸盐在现代生物能量学中的中心地位，加上磷酸化化合物的能量特性，可能表明ATP的原始前体也利用了焦磷酸盐、乙酰磷酸盐和多磷酸盐等化合物中的磷酸盐。然而，生物可利用的磷酸盐在早期地球上可能非常稀缺，这引起了人们对磷酸化分子在生命早期进化中可能发挥的作用的怀疑。在古代地球上，一个很大程度上被忽视的磷氧化还原循环可能提供了磷和能量，还原的磷化合物可能在能量代谢的早期进化中发挥关键作用。在这里，我们推测生物磷化合物可能作为原始能量货币，环境能量来源，或合成磷酸化能量货币的磷来源。这篇评论包括讨论现代生物能量学的进化历史，特别是那些与原始相关的途径，以及古地球上生物可利用磷的地球化学。我们强调磷的重要性，不仅以磷酸盐的形式，早期生物学，并建议未来的研究方向，可能会提高我们的理解的生物能量学的早期演变。
Energy metabolism in extant life is centered around phosphate and the energy-dense phosphoanhydride bonds of adenosine triphosphate (ATP), a deeply conserved and ancient bioenergetic system. Yet, ATP synthesis relies on numerous complex enzymes and has an autocatalytic requirement for ATP itself. This implies the existence of evolutionarily simpler bioenergetic pathways and potentially primordial alternatives to ATP. The centrality of phosphate in modern bioenergetics, coupled with the energetic properties of phosphorylated compounds, may suggest that primordial precursors to ATP also utilized phosphate in compounds such as pyrophosphate, acetyl phosphate and polyphosphate. However, bioavailable phosphate may have been notably scarce on the early Earth, raising doubts about the roles that phosphorylated molecules might have played in the early evolution of life. A largely overlooked phosphorus redox cycle on the ancient Earth might have provided phosphorus and energy, with reduced phosphorus compounds potentially playing a key role in the early evolution of energy metabolism. Here, we speculate on the biological phosphorus compounds that may have acted as primordial energy currencies, sources of environmental energy, or sources of phosphorus for the synthesis of phosphorylated energy currencies. This review encompasses discussions on the evolutionary history of modern bioenergetics, and specifically those pathways with primordial relevance, and the geochemistry of bioavailable phosphorus on the ancient Earth. We highlight the importance of phosphorus, not only in the form of phosphate, to early biology and suggest future directions of study that may improve our understanding of the early evolution of bioenergetics.
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影响因子：
5.1
作者：
Adams, Jamee C.;Steffen, Rachel;Chou, Chau-Wen;Duhamel, Solange;Diaz, Julia M.
通讯作者：
Diaz, Julia M.
影响因子：
3.5
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通讯作者：
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影响因子：
4.6
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Kengen, Serve W. M.
影响因子：
64.8
作者：
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通讯作者：
Canfield, DE