Tuning out the noise: limbic-auditory interactions in tinnitus.
Tuning out the noise: limbic-auditory interactions in tinnitus.
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DOI：
10.1016/j.neuron.2010.04.032
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发表时间：
2010-06-24
期刊：
影响因子：
16.2
通讯作者：
Muehlau, Mark
中科院分区：
文献类型：
--
作者：
Rauschecker, Josef P.;Leaver, Amber M.;Muehlau, Mark
耳鸣是最常见的听觉障碍，仅在美国就影响着约4000万人，由于人口老龄化和噪音暴露增加，其发病率正在上升。耳鸣的治疗方法有哪些？耳鸣的治疗方法有哪些？本文提出了一个可测试的耳鸣模型，该模型基于人类成像的最新发现，并专注于大脑皮层，丘脑和腹侧纹状体的大脑区域。边缘和听觉脑区被认为在丘脑水平上相互作用。虽然耳鸣信号起源于听觉通路的损伤诱导的可塑性，但它可以通过来自边缘区域的反馈连接来调谐，边缘区域阻止耳鸣信号到达听觉皮层。如果边缘区域受到损害，这种“噪音消除”机制就会崩溃，导致慢性耳鸣。希望这种模式最终能够开发出有效的治疗方法。
Tinnitus, the most common auditory disorder, affects about 40 million people in the United States alone, and its incidence is rising due to an aging population and increasing noise exposure. Although several approaches for the alleviation of tinnitus exist, there is as of yet no cure. The present article proposes a testable model for tinnitus that is grounded in recent findings from human imaging and focuses on brain areas in cortex, thalamus, and ventral striatum. Limbic and auditory brain areas are thought to interact at the thalamic level. While a tinnitus signal originates from lesion-induced plasticity of the auditory pathways, it can be tuned out by feedback connections from limbic regions, which block the tinnitus signal from reaching auditory cortex. If the limbic regions are compromised, this “noise-cancellation” mechanism breaks down, and chronic tinnitus results. Hopefully, this model will ultimately enable the development of effective treatment.
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影响因子：
1.7
作者：
Bauer, CA
通讯作者：
Bauer, CA
DOI：
10.1159/000276835
发表时间：
1996-07-01
期刊：
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES
影响因子：
--
作者：
Arnold, W;Bartenstein, P;Schwaiger, M
通讯作者：
Schwaiger, M
影响因子：
1.7
作者：
Dobie, RA
通讯作者：
Dobie, RA
DOI：
10.1073/pnas.191355898
发表时间：
2001-09-25
影响因子：
11.1
作者：
Blood, AJ;Zatorre, RJ
通讯作者：
Zatorre, RJ
DOI：
10.1073/pnas.81.14.4586
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
CRICK, F
通讯作者：
CRICK, F