The influence of placental metabolism on fatty acid transfer to the fetus[S]
The influence of placental metabolism on fatty acid transfer to the fetus[S]
复制标题
胎盘代谢对脂肪酸向胎儿转运的影响[S]
DOI：
--
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发表时间：
2017
影响因子：
6.5
通讯作者：
B. Sengers
中科院分区：
文献类型：
--
作者：
Simone Perazzolo;B. Hirschmugl;C. Wadsack;G. Desoye;Rohan M. Lewis;B. Sengers
决定脂肪酸通过胎盘转移的因素还不完全清楚。本研究采用实验和计算模拟相结合的方法，探讨胎盘转移的非酯化脂肪酸，并确定速率决定过程。用离体人胎盘灌流液研究~（13）C-脂肪酸的摄取、转运和内源性脂肪酸的释放。只有6.2 ± 0.8%的母体13 C-脂肪酸被胎盘吸收并输送到胎儿循环中。在内源性脂质池释放的未标记脂肪酸中，78 ± 5%在母体循环中回收，22 ± 5%在胎儿循环中回收。计算模型表明，脂肪酸代谢是必要的，以解释之间的差异摄取和交付的13 C-脂肪酸。在没有代谢的情况下，该模型高估了13 C-脂肪酸的胎儿分娩15倍。预计代谢率是从母体循环中摄取的主要决定因素。微绒毛膜比基膜具有更大的脂肪酸转运能力。这项研究表明，脂肪酸纳入胎盘脂质池可能会调节其转移到胎儿。未来的工作需要集中在调节脂肪酸纳入脂质池的因素。
The factors determining fatty acid transfer across the placenta are not fully understood. This study used a combined experimental and computational modeling approach to explore placental transfer of nonesterified fatty acids and identify the rate-determining processes. Isolated perfused human placenta was used to study the uptake and transfer of 13C-fatty acids and the release of endogenous fatty acids. Only 6.2 ± 0.8% of the maternal 13C-fatty acids taken up by the placenta was delivered to the fetal circulation. Of the unlabeled fatty acids released from endogenous lipid pools, 78 ± 5% was recovered in the maternal circulation and 22 ± 5% in the fetal circulation. Computational modeling indicated that fatty acid metabolism was necessary to explain the discrepancy between uptake and delivery of 13C-fatty acids. Without metabolism, the model overpredicts the fetal delivery of 13C-fatty acids 15-fold. Metabolic rate was predicted to be the main determinant of uptake from the maternal circulation. The microvillous membrane had a greater fatty acid transport capacity than the basal membrane. This study suggests that incorporation of fatty acids into placental lipid pools may modulate their transfer to the fetus. Future work needs to focus on the factors regulating fatty acid incorporation into lipid pools.
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DOI：
10.1152/ajpendo.00481.2002
发表时间：
2003-06-01
影响因子：
5.1
作者：
Shekhawat, P;Bennett, MJ;Strauss, AW
通讯作者：
Strauss, AW
乙酰 CoA 的动力学：来自快速和慢速乙酰化人肝脏的芳胺 N-乙酰转移酶。
DOI：
--
发表时间：
1991
期刊：
Drug metabolism and disposition: the biological fate of chemicals
影响因子：
--
作者：
Kilbane,AJ;Petroff,T;Weber,WW
通讯作者：
Weber,WW
Caco-2 人类肠道细胞对脂肪酸的摄取。
影响因子：
6.5
作者：
Trotter,PJ;Ho,SY;Storch,J
通讯作者：
Storch,J
DOI：
10.1016/s0021-9258(17)47247-4
发表时间：
1984-07
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
N. Abumrad;Jane H. Park;Charles R. Park
通讯作者：
N. Abumrad;Jane H. Park;Charles R. Park
影响因子：
3.8
作者：
Lager S;Ramirez VI;Gaccioli F;Jang B;Jansson T;Powell TL
通讯作者：
Powell TL