Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.
Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.
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CCR5-α32 杂合性对 HIV-1 易感性的影响：荟萃分析
DOI：
10.1371/journal.pone.0035020
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Zhu H
中科院分区：
文献类型：
--
作者：
Liu S;Kong C;Wu J;Ying H;Zhu H
背景到目前为止，已有许多研究调查了CCR5基因在HIV-1感染者和非感染者之间的分布。然而，关于CCR5基因32位碱基缺失杂合性(CCR5-Δ32)是否会影响HIV-1易感性，目前还没有明确的结果。方法我们对18项研究进行了荟萃分析，对12000多名受试者进行了CCR5-Δ32多态基因分型。用95%可信区间(CI)的优势比(OR)来评估CCR5-Δ32基因多态性与HIV-1易感性的关系。结果与野生型Δ纯合子相比，CCR5-CCR32杂合子在健康对照组和暴露对照组的合并OR值分别为1.02(95%CI，0.88~1.19)和0.95(95%CI，0.71~1.26)。在按种族、样本大小和CCR5-Δ32基因分型方法进行的分层分析中也发现了类似的结果。结论荟萃分析显示CCR5-Δ32杂合子对HIV-1易感性无显著影响。
Background So far, many studies have investigated the distribution of CCR5 genotype between HIV-1 infected patients and uninfected people. However, no definite results have been put forward about whether heterozygosity for a 32-basepair deletion in CCR5 gene (CCR5-Δ32) can affect HIV-1 susceptibility. Methods We performed a meta-analysis of 18 studies including more than 12000 subjects for whom the CCR5-Δ32 polymorphism was genotyped. Odds ratio (OR) with 95% confidence interval (CI) were employed to assess the association of CCR5-Δ32 polymorphism with HIV-1 susceptibility. Results Compared with the wild-type CCR5 homozygotes, the pooled OR for CCR5-Δ32 heterozygotes was 1.02 (95%CI, 0.88–1.19) for healthy controls (HC) and 0.95 (95%CI, 0.71–1.26) for exposed uninfected (EU) controls. Similar results were found in stratified analysis by ethnicity, sample size and method of CCR5-Δ32 genotyping. Conclusions The meta-analysis indicated that HIV-1 susceptibility is not significantly affected by heterozygosity for CCR5-Δ32.
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