Humoral Immunity in the Gut Selectively Targets Phenotypically Virulent Attaching-and-Effacing Bacteria for Intraluminal Elimination.
Humoral Immunity in the Gut Selectively Targets Phenotypically Virulent Attaching-and-Effacing Bacteria for Intraluminal Elimination.
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DOI：
10.1016/j.chom.2015.04.001
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发表时间：
2015-05-13
影响因子：
30.3
通讯作者：
Núñez G
中科院分区：
文献类型：
--
作者：
Kamada N;Sakamoto K;Seo SU;Zeng MY;Kim YG;Cascalho M;Vallance BA;Puente JL;Núñez G
由肠道细菌表达的毒力因子对于病原体定殖和诱导肠道疾病是关键的，但是宿主免疫调节病原体毒力的机制在很大程度上是未知的。在这里，我们表明，特异性抗体反应所需的毒性基因表达的下调，在啮齿类柠檬酸杆菌，肠道病原体，人体感染的附着和消失的细菌模型。在缺乏针对病原体的抗体的情况下，表型毒性C。啮齿类，积累和感染上皮，并随后侵入固有层，造成宿主死亡。感染后诱导的IgG识别毒力因子并结合肠腔内的毒性细菌，导致它们被中性粒细胞吞噬，而表型无毒的病原体保留在肠腔内，并最终被微生物群竞争。因此，先天性和适应性免疫系统的相互作用选择性地靶向毒性C。啮齿类动物在肠腔，以促进病原体根除和宿主生存。
Virulence factors expressed by enteric bacteria are pivotal for pathogen colonization and induction of intestinal disease, but the mechanisms by which host immunity regulates pathogen virulence are largely unknown. Here we show that specific antibody responses are required for down-regulation of virulence gene expression in Citrobacter rodentium, an enteric pathogen that models human infections with attaching-and-effacing bacteria. In the absence of antibodies against the pathogen, phenotypically virulent C. rodentium, accumulated and infected the epithelium, and subsequently invaded the lamina propia causing host lethality. IgG induced after infection recognized virulence factors and bound virulent bacteria within the intestinal lumen leading to their engulfment by neutrophils, while phenotypically avirulent pathogens remained in the intestinal lumen and were eventually out-competed by the microbiota. Thus, the interplay of the innate and adaptive immune system selectively targets virulent C. rodentium in the intestinal lumen to promote pathogen eradication and host survival.
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影响因子：
6.7
作者：
Bergstrom KS;Kissoon-Singh V;Gibson DL;Ma C;Montero M;Sham HP;Ryz N;Huang T;Velcich A;Finlay BB;Chadee K;Vallance BA
通讯作者：
Vallance BA
DOI：
10.1084/jem.20020400
发表时间：
2002-08-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Spiekermann GM;Finn PW;Ward ES;Dumont J;Dickinson BL;Blumberg RS;Lencer WI
通讯作者：
Lencer WI
影响因子：
32.4
作者：
Basu R;O'Quinn DB;Silberger DJ;Schoeb TR;Fouser L;Ouyang W;Hatton RD;Weaver CT
通讯作者：
Weaver CT
影响因子：
6.4
作者：
Martinez, MB;Taddei, CR;Girón, JA
通讯作者：
Girón, JA
影响因子：
3.1
作者：
Simmons, CP;Clare, S;Dougan, G
通讯作者：
Dougan, G