Prenatal Cocaine Exposure Impacts Language and Reading Into Late Adolescence: Behavioral and ERP Evidence.
Prenatal Cocaine Exposure Impacts Language and Reading Into Late Adolescence: Behavioral and ERP Evidence.
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DOI：
10.1080/87565641.2017.1362698
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发表时间：
2017
影响因子：
1.5
通讯作者：
Mayes L
中科院分区：
文献类型：
--
作者：
Landi N;Avery T;Crowley MJ;Wu J;Mayes L
现有研究记录了产前可卡因暴露（PCE）儿童相对于非药物暴露（NDE）儿童的语言障碍，这表明可卡因改变了支持语言的神经生物系统的发育。目前的研究检查了老年青少年语言功能的行为和神经（电生理）指数。具体来说，我们比较了 PCE (N = 59) 和 NDE (N = 51) 青少年在一系列认知和语言评估方面的表现，这些评估涉及单词阅读、阅读理解、语义和语法处理以及智商。此外，我们还通过三个实验任务检查了这些孩子的事件相关电位（ERP）反应，这些任务检查了单词级语音处理（韵律启动）、单词级语义处理（语义启动）和句子级语义处理（语义异常）。在控制了社会经济地位和接触其他物质后，研究结果显示，许多阅读和语言评估存在缺陷。此外，ERP 数据揭示了非典型的正字法到音系映射（N1/P2 响应减少）以及非典型的韵律和语义处理（N400 响应）。这些发现表明，PCE 持续影响青少年后期的语言和阅读技能。
Extant research documents impaired language among children with prenatal cocaine exposure (PCE) relative to nondrug exposed (NDE) children, suggesting that cocaine alters development of neurobiological systems that support language. The current study examines behavioral and neural (electrophysiological) indices of language function in older adolescents. Specifically, we compare performance of PCE (N = 59) and NDE (N = 51) adolescents on a battery of cognitive and linguistic assessments that tap word reading, reading comprehension, semantic and grammatical processing, and IQ. In addition, we examine event related potential (ERP) responses in in a subset of these children across three experimental tasks that examine word level phonological processing (rhyme priming), word level semantic processing (semantic priming), and sentence level semantic processing (semantic anomaly). Findings reveal deficits across a number of reading and language assessments, after controlling for socioeconomic status and exposure to other substances. Additionally, ERP data reveal atypical orthography to phonology mapping (reduced N1/P2 response) and atypical rhyme and semantic processing (N400 response). These findings suggest that PCE continues to impact language and reading skills into the late teenage years.
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