3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI.
3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI.
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DOI：
10.1002/hbm.20905
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发表时间：
2010-05
影响因子：
4.8
通讯作者：
DeCarli, Charles S.
中科院分区：
文献类型：
--
作者：
Apostolova, Liana G.;Thompson, Paul M.;Green, Amity E.;Hwang, Kristy S.;Zoumalan, Charleen;Jack, Clifford R., Jr.;Harvey, Danielle J.;Petersen, Ronald C.;Thal, Leon J.;Aisen, Paul S.;Toga, Arthur W.;Cummings, Jeffrey L.;DeCarli, Charles S.
关键词：
我们将海马放射状萎缩映射技术应用于阿尔茨海默病合作研究MCI多奈哌齐/维生素E试验成像组中169名遗忘型轻度认知障碍（MCI）参与者的基线和随访磁共振成像数据。随访3年，无至轻度海马萎缩（MTA评分< 2分）的受试者中有60%，中度至重度海马萎缩（MTA ≥ 2分）的受试者中有33.8%转化为阿尔茨海默病（AD）。基线时，MTA ≥ 2组与MTA < 2组相比显示出更大的左侧海马萎缩趋势（P校正= 0.08）。较高的MTA评分与下托和CA 1 -3亚区的进行性萎缩相关。MTA < 2组在随访时表现出显著的双侧萎缩进展（左侧P校正= 0.008;右侧P校正= 0.05）。相对于MTA < 2的非转化者，MTA < 2的转化者在随访时显示下托和CA 1进一步受累，并且CA 2 -3额外受累。右侧CA 1萎缩与转化为痴呆显著相关（右侧CA 1径向距离大于1 mm的受试者转化风险降低50%）。更大的CA 1和下托萎缩可以在早期被证实，并预测未来转化为AD，而CA 2 -3的参与变得更加明显，随着疾病的进展。
We applied the hippocampal radial atrophy mapping technique to the baseline and follow-up magnetic resonance image data of 169 amnestic mild cognitive impairment (MCI) participants in the imaging arm of the Alzheimer's Disease Cooperative Study MCI Donepezil/Vitamin E trial. Sixty percent of the subjects with none to mild hippocampal atrophy rated with the visual medial temporal atrophy rating scale (MTA score < 2) and 33.8% of the subjects with moderate to severe (MTA ≥ 2) hippocampal atrophy converted to Alzheimer's disease (AD) during 3-year follow-up. MTA ≥ 2 showed a trend for greater left sided hippocampal atrophy versus MTA < 2 groups at baseline (Pcorrected = 0.08). Higher MTA scores were associated with progressive atrophy of the subiculum and the CA1–3 subregions. The MTA < 2 group demonstrated significant bilateral atrophy progression at follow-up (left Pcorrected = 0.008; right Pcorrected = 0.05). Relative to MTA < 2 nonconverters, MTA < 2 converters showed further involvement of the subiculum and CA1 and additional involvement of CA2–3 at follow-up. Right CA1 atrophy was significantly associated with conversion to dementia (for 1 mm greater right CA1 radial distance subjects had 50% reduced hazard for conversion). Greater CA1 and subicular atrophy can be demonstrated early and is predictive of future conversion to AD, whereas CA2–3 involvement becomes more evident as the disease progresses.
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影响因子：
1.3
作者：
COLLINS, DL;NEELIN, P;EVANS, AC
通讯作者：
EVANS, AC
影响因子：
9.9
作者：
Jack, CR;Shiung, MM;Petersen, RC
通讯作者：
Petersen, RC
影响因子：
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作者：
Haroutunian, V;Perl, DP;Mohs, RC
通讯作者：
Mohs, RC
影响因子：
9.9
作者：
Csernansky, JG;Wang, L;Miller, MI
通讯作者：
Miller, MI
影响因子：
5.7
作者：
Morra JH;Tu Z;Apostolova LG;Green AE;Avedissian C;Madsen SK;Parikshak N;Toga AW;Jack CR Jr;Schuff N;Weiner MW;Thompson PM;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative