Increased brain white matter axial diffusivity associated with fatigue, pain and hyperalgesia in Gulf War illness.
Increased brain white matter axial diffusivity associated with fatigue, pain and hyperalgesia in Gulf War illness.
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DOI：
10.1371/journal.pone.0058493
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Baraniuk JN
中科院分区：
文献类型：
--
作者：
Rayhan RU;Stevens BW;Timbol CR;Adewuyi O;Walitt B;VanMeter JW;Baraniuk JN
1990年和1991年的海湾战争暴露已导致25%至30%的部署人员出现慢性疲劳、疼痛、痛觉过敏、认知和情感障碍综合症。海湾战争退伍军人(n = 31人)和久坐不动的退伍军人和平民对照组(n = 20人)完成了扩散张量成像的功能磁共振扫描。结合测光、疼痛和疲劳的主观报告与脑白质弥散特性相关联，以确定与症状构成相关的区域。海湾战争疾病受试者有显著的相关疲劳、疼痛、痛觉过敏和右额枕下束轴向扩散率增加。ROC产生的阈值和随后的二元回归分析基于右额枕下束的轴向弥散系数预测了CMI的分类。在二分回归分析中，这些相关性在对照组中是不存在的。右额枕下束可能是海湾战争疾病的潜在生物标志物。这个区域连接了参与疲劳、疼痛、情绪和奖励处理的皮质区域，以及认知中的右侧腹侧注意网络。轴突神经病理机制(S)解释轴向扩散性增加可能是海湾战争疾病最突出的症状。
Gulf War exposures in 1990 and 1991 have caused 25% to 30% of deployed personnel to develop a syndrome of chronic fatigue, pain, hyperalgesia, cognitive and affective dysfunction. Gulf War veterans (n = 31) and sedentary veteran and civilian controls (n = 20) completed fMRI scans for diffusion tensor imaging. A combination of dolorimetry, subjective reports of pain and fatigue were correlated to white matter diffusivity properties to identify tracts associated with symptom constructs. Gulf War Illness subjects had significantly correlated fatigue, pain, hyperalgesia, and increased axial diffusivity in the right inferior fronto-occipital fasciculus. ROC generated thresholds and subsequent binary regression analysis predicted CMI classification based upon axial diffusivity in the right inferior fronto-occipital fasciculus. These correlates were absent for controls in dichotomous regression analysis. The right inferior fronto-occipital fasciculus may be a potential biomarker for Gulf War Illness. This tract links cortical regions involved in fatigue, pain, emotional and reward processing, and the right ventral attention network in cognition. The axonal neuropathological mechanism(s) explaining increased axial diffusivity may account for the most prominent symptoms of Gulf War Illness.
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影响因子：
2.5
作者：
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影响因子：
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作者：
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DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y